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Publikováno v:
Proceedings of the National Academy of Sciences. 117:30699-30709
In recent years, the prevalence of carbapenem-resistant Enterobacteriaceae (CRE) has risen substantially, and the study of CRE resistance mechanisms has become increasingly important for antibiotic development. Although much research has focused on g
Autor:
Rolf Müller, Robert Landick, Mirjana Lilic, Jennifer Herrmann, Rachel A. Mooney, Hande Boyaci, Elizabeth A. Campbell, Nathaniel Braffman, James Chen, Seth A. Darst, Elizabeth A. Hubin
Publikováno v:
Proceedings of the National Academy of Sciences. 117:30423-30432
Rifampicin (Rif) is a first-line therapeutic used to treat the infectious disease tuberculosis (TB), which is caused by the pathogen Mycobacterium tuberculosis (Mtb). The emergence of Rif-resistant (RifR) Mtb presents a need for new antibiotics. Rif
Autor:
Michael A. Ochsenkühn, Kristin C. Gunsalus, Miraflor P. Santos, Ahmed A. Shibl, Ashley Isaac, Gregory Behringer, Shady A. Amin, Cong Fei, Marc Arnoux, Christian R. Voolstra, Anny Cárdenas, Nizar Drou
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Phytoplankton are major primary producers in the marine environment that excrete a wide range of metabolites. These exudates support the growth of surrounding bacteria that in turn provide phytoplankton cells with resources and growth co
Publikováno v:
Proc Natl Acad Sci U S A
Melatonin (Mel) promotes sleep through G protein-coupled receptors. However, the downstream molecular target(s) is unknown. We identified the Caenorhabditis elegans BK channel SLO-1 as a molecular target of the Mel receptor PCDR-1-. Knockout of pcdr-
Autor:
Abhishek Singh, Xinbo Zhang, Qian Li, Bonne M Thompson, Yajaira Suárez, Jeffrey G McDonald, Jose Ordovas-Montanes, Carlos Fernández-Hernando, Rolando García Milian, Wen Ding, Elisa Araldi, Alberto Canfrán-Duque, Binod Aryal, Emily L. Goldberg, Yuhua Fan, Vishwa Deep Dixit, George Tellides, Elina Ikonen
Publikováno v:
Proc Natl Acad Sci U S A
Cholesterol biosynthetic intermediates, such as lanosterol and desmosterol, are emergent immune regulators of macrophages in response to inflammatory stimuli or lipid overloading, respectively. However, the participation of these sterols in regulatin
Autor:
Randall T. Hayden, Jose Ferrolino, Daniel R. Evans, Daria Van Tyne, Jason W. Rosch, Joshua Wolf, Anh N. Vo, Gabriela Maron, Gayatri Shankar Chilambi, Michael S. Gilmore, Hayley R. Nordstrom
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Immunocompromised patients are at increased risk for multidrug-resistant infections, due to broad-spectrum antibiotic exposure and a host environment with limited innate defenses. This study explored how vancomycin-resistant Enterococcus
Autor:
Gloria S. Huang, Roberto Angioli, Titus J. Boggon, Weilai Dong, Ludmil B. Alexandrov, Gulden Menderes, Elena Bonazzoli, Francesco Raspagliesi, Richard P. Lifton, Chanhee Han, Aranzazu Manzano, Franco Odicino, Peter E. Schwartz, Antonella Ravaggi, Kaya Bilguvar, Emanuele Perrone, Laura Zanotti, Elena Ratner, Salvatore Lopez, Laura Ardighieri, Joseph Schlessinger, Valentina Pirazzoli, Jungmin Choi, Gary Altwerger, Francesca Pettinella, Siming Zhao, Alessandro D. Santin, Masoud Azodi, Carla Donzelli, Luca Zammataro, Natalia Buza, Paola Todeschini, Burak Zeybek, Dan-Arin Silasi, Eliana Bignotti, Stefania Bellone, Sergio Pecorelli, Pei Hui, Chiara Romani, Serena Wong, Amy L. Stiegler, Emiliano Cocco, Paola Manara, Giovanni Scambia, Anna Bianchi
Publikováno v:
Proceedings of the National Academy of Sciences. 116:22730-22736
The prognosis of advanced/recurrent cervical cancer patients remains poor. We analyzed 54 fresh-frozen and 15 primary cervical cancer cell lines, along with matched-normal DNA, by whole-exome sequencing (WES), most of which harboring Human-Papillomav
Autor:
Philipp Olias, Qiuling Wang, Eugene Park, Wayne M. Yokoyama, Zhou Huang, L. David Sibley, Sumit K. Matta
Publikováno v:
Proceedings of the National Academy of Sciences. 116:17480-17491
In contrast to the importance of type II interferon-γ (IFN-γ) in control of toxoplasmosis, the role of type I IFN is less clear. We demonstrate here that TgIST, a secreted effector previously implicated in blocking type II IFN-γ signaling, also bl
Autor:
Mirjana Persaud, Laura Pasqualucci, Katia Basso, Jiguang Wang, Raul Rabadan, Riccardo Dalla-Favera, Carla Grandori, Claudio Scuoppo, Francesc Bosch, Sandeep K. Mittan, Giorgio Inghirami
Publikováno v:
Proceedings of the National Academy of Sciences. 116:16981-16986
To repurpose compounds for diffuse large B cell lymphoma (DLBCL), we screened a library of drugs and other targeted compounds approved by the US Food and Drug Administration on 9 cell lines and validated the results on a panel of 32 genetically chara
Autor:
Elizabeth S. Sattely, Ramesha B. Thimmappa, Anne Osbourn, Hannah E. Hodgson, Jason Leigh Vincent, Michael J. Stephenson, Ricardo De La Peña
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Limonoids are natural products made by members of the Meliaceae and Rutaceae families. Some limonoids (e.g., azadirachtin) are toxic to insects yet harmless to mammals. The use of limonoids in crop protection and other applications curre