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Autor:
Randall T. Hayden, Jose Ferrolino, Daniel R. Evans, Daria Van Tyne, Jason W. Rosch, Joshua Wolf, Anh N. Vo, Gabriela Maron, Gayatri Shankar Chilambi, Michael S. Gilmore, Hayley R. Nordstrom
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Immunocompromised patients are at increased risk for multidrug-resistant infections, due to broad-spectrum antibiotic exposure and a host environment with limited innate defenses. This study explored how vancomycin-resistant Enterococcus
Autor:
Gloria S. Huang, Roberto Angioli, Titus J. Boggon, Weilai Dong, Ludmil B. Alexandrov, Gulden Menderes, Elena Bonazzoli, Francesco Raspagliesi, Richard P. Lifton, Chanhee Han, Aranzazu Manzano, Franco Odicino, Peter E. Schwartz, Antonella Ravaggi, Kaya Bilguvar, Emanuele Perrone, Laura Zanotti, Elena Ratner, Salvatore Lopez, Laura Ardighieri, Joseph Schlessinger, Valentina Pirazzoli, Jungmin Choi, Gary Altwerger, Francesca Pettinella, Siming Zhao, Alessandro D. Santin, Masoud Azodi, Carla Donzelli, Luca Zammataro, Natalia Buza, Paola Todeschini, Burak Zeybek, Dan-Arin Silasi, Eliana Bignotti, Stefania Bellone, Sergio Pecorelli, Pei Hui, Chiara Romani, Serena Wong, Amy L. Stiegler, Emiliano Cocco, Paola Manara, Giovanni Scambia, Anna Bianchi
Publikováno v:
Proceedings of the National Academy of Sciences. 116:22730-22736
The prognosis of advanced/recurrent cervical cancer patients remains poor. We analyzed 54 fresh-frozen and 15 primary cervical cancer cell lines, along with matched-normal DNA, by whole-exome sequencing (WES), most of which harboring Human-Papillomav
Autor:
Kimberly A. Toops, Nilsa La Cunza, Li Xuan Tan, Timothy A. Blenkinsop, Aparna Lakkaraju, Colin J. Germer, Gulpreet Kaur, Marie Fernandes, Gurugirijha Rathnasamy
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 36
Abnormally enlarged early endosomes (EEs) are pathological features of neurodegenerative diseases, yet insight into the mechanisms and consequences of EE expansion remains elusive. Here, we report swollen apical EEs in the retinal pigment epithelium
Autor:
Namrata R. Chowdhury, Brieann C. Satterfield, Rajendra P. Gajula, Elena Skornyakov, Kenneth I. Porter, Benita Middleton, Shobhan Gaddameedhi, Hans P. A. Van Dongen, Debra J. Skene
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance Shift workers, whose schedules are misaligned relative to their suprachiasmatic nuclei (SCN) circadian pacemaker, are at elevated risk of metabolic disorders. In a study of simulated day- versus night-shift work followed by a constant ro
Autor:
Annabel Wilz, Chun-Cheih Chao, Jessica E. Kenison, Jack P. Antel, Veit Rothhammer, Luke M. Healy, Maisa C. Takenaka, Emily C. Tjon, Francisco J. Quintana, Kalil Alves de Lima, Manon Blain, Davis M. Borucki
Publikováno v:
Proceedings of the National Academy of Sciences. 114:2012-2017
Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the CNS that causes disability in young adults as a result of the irreversible accumulation of neurological deficits. Although there are potent disease-modifying agents fo
Autor:
Yusuke Kiyooka, Hiroyuki Sasanuma, Andrew D. Cherniack, Ken Tsutsui, Elsa Callen Moreu, Shinichiro Nakada, Hisashi Tanaka, Suguru Morimoto, Haruna Fujiike, André Nussenzweig, Shunichi Takeda, Maminur Rahman, Masataka Tsuda, Junji Itou, Liton Kumar Saha, Masakazu Toi, Shintaro Yamada
Publikováno v:
Proceedings of the National Academy of Sciences. 115
Women having BRCA1 germ-line mutations develop cancer in breast and ovary, estrogen-regulated tissues, with high penetrance. Binding of estrogens to the estrogen receptor (ER) transiently induces DNA double-strand breaks (DSBs) by topoisomerase II (T
Autor:
Ingrid Wernstedt Asterholm, John M. Shelton, Belén Chanclón, Anna Benrick, Yanling Wu, Peter Micallef, Laila Hadi, Elisabet Stener-Victorin
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Adiponectin, together with adipocyte size, is the strongest factor associated with insulin resistance in women with polycystic ovary syndrome (PCOS). This study investigates the causal relationship between adiponectin levels and metabolic and reprodu
Autor:
Liane Renno, Gabriela Krasteva-Christ, Burkhard Schütz, Miriam Wolff, Amir Rafiq, Lars Wessels, Tamara Papadakis, Wolfgang Kummer, Katharina Filipski, Klaus Deckmann, Innokentij Jurastow, Vladimir Chubanov, Jochen Klein, Eberhard Weihe, Mike Althaus, Thomas Bschleipfer, Martin Fronius, Thomas Gudermann
Publikováno v:
Proceedings of the National Academy of Sciences. 111:8287-8292
Chemosensory cells in the mucosal surface of the respiratory tract ("brush cells") use the canonical taste transduction cascade to detect potentially hazardous content and trigger local protective and aversive respiratory reflexes on stimulation. So
Publikováno v:
Proceedings of the National Academy of Sciences. 110:6151-6156
Monoamines, including dopamine (DA), have been linked to aggression in various species. However, the precise role or roles served by the amine in aggression have been difficult to define because dopaminergic systems influence many behaviors, and all
Publikováno v:
Proceedings of the National Academy of Sciences. 109:17681-17686
The heart peptide hormone atrial natriuretic peptide (ANP) regulates blood pressure by stimulating guanylyl cyclase-A to produce cyclic guanosine monophosphate (cGMP). ANP and guanylyl cyclase-A are also expressed in many brain areas, but their physi