Zobrazeno 1 - 10
of 77
pro vyhledávání: ''
Autor:
Anders Allgardsson, Christine Akfur, Andreas Hörnberg, Lotta Berg, Fredrik Ekström, Franz Worek, Anna Linusson
Publikováno v:
Proceedings of the National Academy of Sciences. 113:5514-5519
Organophosphorus nerve agents interfere with cholinergic signaling by covalently binding to the active site of the enzyme acetylcholinesterase (AChE). This inhibition causes an accumulation of the neurotransmitter acetylcholine, potentially leading t
Autor:
Liane Renno, Gabriela Krasteva-Christ, Burkhard Schütz, Miriam Wolff, Amir Rafiq, Lars Wessels, Tamara Papadakis, Wolfgang Kummer, Katharina Filipski, Klaus Deckmann, Innokentij Jurastow, Vladimir Chubanov, Jochen Klein, Eberhard Weihe, Mike Althaus, Thomas Bschleipfer, Martin Fronius, Thomas Gudermann
Publikováno v:
Proceedings of the National Academy of Sciences. 111:8287-8292
Chemosensory cells in the mucosal surface of the respiratory tract ("brush cells") use the canonical taste transduction cascade to detect potentially hazardous content and trigger local protective and aversive respiratory reflexes on stimulation. So
Autor:
Bertha Dominguez, Brian K. Kaspar, Ronald W. Oppenheim, Yoshie Sugiura, Prafulla Aryal, Thomas W. Gould, Weichun Lin, Kuo-Fen Lee, Mark E. Hester, Mahru C. An, Chien-Ping Ko, Jiefei Yang, Daniel Padgett
Publikováno v:
Proceedings of the National Academy of Sciences. 107:10702-10707
Emerging evidence suggests that the neurotransmitter acetylcholine (ACh) negatively regulates the development of the neuromuscular junction, but it is not clear if ACh exerts its effects exclusively through muscle ACh receptors (AChRs). Here, we used
Publikováno v:
Proceedings of the National Academy of Sciences. 104:12312-12317
The molecular mechanism of desensitization of soluble guanylyl cyclase (sGC), the NO receptor, has long remained unresolved. Posttranslational modification and redox state have been postulated to affect sGC sensitivity to NO but evidence has been lac
Autor:
Qian Sheng Yu, Tony Giordano, Nigel H. Greig, Carla Scali, Debomoy K. Lahiri, Tadanobu Utsuki, Katsutoshi Furukawa, Kumar Sambamurti, Harold W. Holloway, Donald K. Ingram, Jacek Mamczarz, Giancarlo Pepeu, Demao Chen, Yue Wang, Arnold Brossi
Publikováno v:
Proceedings of the National Academy of Sciences. 102:17213-17218
Like acetylcholinesterase, butyrylcholinesterase (BChE) inactivates the neurotransmitter acetylcholine (ACh) and is hence a viable therapeutic target in Alzheimer's disease, which is characterized by a cholinergic deficit. Potent, reversible, and bra
Autor:
Teruyoshi Kume, Miwako Tsukiji, Yoji Neishi, Renan Sukmawan, Seiichi Mochizuki, Kiyoshi Yoshida, Takashi Akasaka, Fumihiko Kajiya, Takehiro Miyasaka, Yasuo Ogasawara, Masami Goto, Takahiro Kawamoto
Publikováno v:
Proceedings of the National Academy of Sciences. 102:11456-11461
Although bioavailability of NO in the coronary circulation is commonly evaluated by acetylcholine (ACh)-induced vasodilation, a change in plasma NO concentration and its relation to the flow response after injection of ACh are still unknown. Thus, we
Nonvesicular release of acetylcholine is required for axon targeting in the Drosophila visual system
Publikováno v:
Proceedings of the National Academy of Sciences. 101:15213-15218
We report evidence for a developmental role of acetylcholine in axon pathfinding in the Drosophila visual system. Acetylcholine was detected on photoreceptor axons during their navigation to target sites in the brain, a time well before the formation
Autor:
Jan Born, Steffen Gais
Publikováno v:
Proceedings of the National Academy of Sciences. 101:2140-2144
The neurotransmitter acetylcholine is considered essential for proper functioning of the hippocampus-dependent declarative memory system, and it represents a major neuropharmacological target for the treatment of memory deficits, such as those in Alz
Publikováno v:
Proceedings of the National Academy of Sciences. 100:15212-15217
We have compared the contributions of gap junctional communication and chemical signaling via H 2 O 2 to NO-independent relaxations evoked by the Ca 2+ ionophore A23187 and acetylcholine (ACh) in rabbit ilio-femoral arteries. Immunostaining confirmed
Publikováno v:
Proceedings of the National Academy of Sciences. 100:6169-6173
Drug addiction poses serious social, medical, and economic problems, but effective treatments for drug addiction are still limited. Cocaine and morphine elevate dopamine levels in the nucleus accumbens (NAc), and the overwhelming actions of dopamine