Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Michael T. Wilson"'
Autor:
Rebecca S. Silkstone, Gary Silkstone, Kristian Kallberg, Leif Bülow, Khuanpiroon Ratanasopa, Michael T. Wilson, Brandon J. Reeder, Chris E. Cooper, Michelle Simons, Andrea Mozzarelli, Luca Ronda
Publikováno v:
Biochemical Journal
Hemoglobin (Hb)-based oxygen carriers (HBOC) have been engineered to replace or augment the oxygen-carrying capacity of erythrocytes. However, clinical results have generally been disappointing due to adverse side effects linked to intrinsic heme-med
Publikováno v:
Biochemical Journal. 465:127-137
Cytoglobin (Cygb) is a hexa-co-ordinate haem protein from the globin superfamily with a physiological function that is unclear. We have previously reported that the haem co-ordination is changed in the presence of lipids, potentially transforming the
Autor:
Jonathan A. R. Worrall, Gary Silkstone, Ann N. Edzuma, Katie L. I. M. Blundell, Badri S. Rajagopal, Valerian E. Kagan, Lewis A. Fraser, Dimitri A. Svistunenko, Michael A. Hough, Alexandr A. Kapralov, Michael T. Wilson, Julea N. Butt
Publikováno v:
Biochemical Journal. 456:441-452
We have investigated whether the pro-apoptotic properties of the G41S mutant of human cytochrome c can be explained by a higher than wild-type peroxidase activity triggered by phospholipid binding. A key complex in mitochondrial apoptosis involves cy
Autor:
Peter Nicholls, Brandon J. Reeder, Chris E. Cooper, Michael T. Wilson, Radu Silaghi-Dumitrescu
Publikováno v:
Biochemical Journal. 403:391-395
Ferryl (Fe(IV)=O) species are involved in key enzymatic processes with direct biomedical relevance; among others, the uncontrolled reactivities of ferryl Mb (myoglobin) and Hb (haemoglobin) have been reported to be central to the pathology of rhabdom
Publikováno v:
Biochemical Society Transactions. 30:280-285
This article reviews the role of free radicals in causing oxidative stress during exercise. High intensity exercise induces oxidative stress and although there is no evidence that this affects sporting performance in the short term, it may have longe
Autor:
Nathan Davies, Martyn A. Sharpe, Chris E. Cooper, Dimitri A. Svistunenko, Jacqueline Dunne, Christine Blenkinsop, Peter Nicholls, Michael T. Wilson
Publikováno v:
Biochemical Journal. 351:595-605
The paramagnetic species in human metHb and horse metmyoglobin (metMb) have been studied at low temperature using EPR spectroscopy. The high-spin (HS) haem signal in aquometMb has a greater rhombic distortion than the HS metHb signal. Nevertheless, t
Publikováno v:
Biochemical Society Transactions. 27:A127-A127
Autor:
Harjit K. Singh, Michael T. Wilson
Publikováno v:
Biochemical Society Transactions. 18:1272-1273
Publikováno v:
Biochemical Society Transactions. 26:S320-S320
Publikováno v:
Biochemical Society Transactions. 26:S323-S323
INTRODUCTION NO is both a cellular messenger and an inhibitor of cytochrome aa3. Previous studies (1-4) have shown that it can react either with CU$+ or with cyt. a32+. In its final inhibited state the binuclear centre is in the reduced cyt. u~~+NOCU