Zobrazeno 1 - 10
of 564
pro vyhledávání: '"Lipids"'
Autor:
Elie Antoun, Helena L. Fisk, Caroline E. Childs, Elizabeth A. Miles, Carolina Paras-Chavez, Philip C. Calder, Karen A. Lillycrop, Robert Ayres, Ondrej Kuda, Paul S. Noakes, Jan Kopecký
Publikováno v:
Clinical Science. 135:185-200
Obesity is believed to be associated with a dysregulated endocannabinoid system which may reflect enhanced inflammation. However, reports of this in human white adipose tissue (WAT) are limited and inconclusive. Marine long-chain omega-3 polyunsatura
Publikováno v:
Clinical Science. 134:2295-2313
The lectin-like oxidized low-density-lipoprotein (oxLDL) receptor-1 (LOX-1) has been shown to induce angiotensin II (AngII) type 1 receptor (AT1) activation, contributing to vascular dysfunction. Preeclampsia is a pregnancy complication characterized
Autor:
Hui-Kim Yap, Liangjian Lu, Henry H Yang, Lauretta D Low, Chang-Yien Chan, Caroline G.L. Lee, Kar-Hui Ng, Hanry Yu, Jinmiao Chen
Publikováno v:
Clinical Science. 134:225-237
Circulating factors have been implicated in the pathogenesis of minimal change disease (MCD), and may have direct effects on cholesterol metabolism. This study investigated the pathogenesis of hypercholesterolemia in an IL-13 overexpression rat model
Autor:
Ilya Khantalin, Stéphane Ramin-Mangata, Brice Nativel, Stéphanie Billon-Crossouard, Mikaël Croyal, Rose Hélène Blanchard, Etienne Guillot, Kévin Chemello, Michel Krempf, Valentin Blanchard, Gilles Lambert, Audrey Aguesse, Bruno Poirier, Philip Janiak, Elise F. Villard, Christophe Boixel, Jean-Christophe Le Bail, Aurélie Thedrez, Thi-Thu-Trang Tran
Publikováno v:
Clinical Science
Clinical Science, Portland Press, 2018, 132 (10), pp.1075-1083. ⟨10.1042/CS20180040⟩
Clinical Science, Portland Press, 2018, 132 (10), pp.1075-1083. ⟨10.1042/CS20180040⟩
Therapeutic antibodies targeting proprotein convertase subtilisin kexin type 9 (PCSK9) (e.g. alirocumab) lower low-density lipoprotein cholesterol (LDL-C) and lipoprotein (a) [Lp(a)] levels in clinical trials. We recently showed that PCSK9 enhances a
Autor:
Dong Jun Liu, Yong Wei Nie
Publikováno v:
Biochemical Journal. 474:3167-3177
Irisin, a myokine derived from the extracellular domain of FNDC5, has been shown to mediate thermogenesis of white adipose tissue. Biochemical data have shown that N-glycosylation of FNDC5 is unlikely to affect ligand or receptor activation of irisin
Publikováno v:
Clinical Science. 133:777-788
The diagnosis of short stature (SS) is of widespread importance for later treatment. In the present paper, a metabolomic method was used to analyze the metabolic characteristics of SS children caused by endocrine metabolic diseases in order to unders
Autor:
Navin Michael, Giang Thi Thu Le, S. Sendhil Velan, Venkatesh Gopalan, Rengaraj Anantharaj, Sanjay Kumar Verma, Kavita Kaur, Suresh Anand Sadananthan, Jadegoud Yaligar, Jorming Goh
Publikováno v:
Bioscience Reports
Investigations of long-term exercise interventions in humans to reverse obesity is expensive and is hampered by poor compliance and confounders. In the present study, we investigated intrahepatic and muscle fat, visceral and subcutaneous fat pads, pl
Autor:
Zhao-Hong Chen, Jing Zhang, Li-Hua Li, Feng-Hui An, Chenhui Zhao, Qiao-Wei Jia, Jie-Yin Liu, Mingyue Ji, En-Zhi Jia, Wen-Zhu Ma, Zhijian Yang, Lian-Sheng Wang
Publikováno v:
Bioscience Reports
Aims: To investigate the relationship between the miR-130a polymorphism rs731384 and coronary artery disease (CAD) and to further explore the molecular mechanism of the pathogenesis of CAD, an observational single-center study was conducted. Method:
Autor:
Bang-Dang Chen, Yang Li, Yong-Tao Wang, Min-Tao Gai, Yi-Ning Yang, Dilare Adi, Yi-Tong Ma, Jialin Abuzhalihan, Zhen-Yan Fu, Xiang Xie, Xiang Ma, Fen Liu, Xiao-Mei Li
Publikováno v:
Bioscience Reports
Hyperlipidemia is one of the main risk factors for coronary artery disease (CAD). In the present study, we aimed to explore whether the single-nucleotide polymorphisms (SNPs) in amyloid precursor-like protein (APLP) 2 (APLP2) gene were associated wit
Autor:
Valéria S. Nunes, Marisa Passarelli, Isabela M. Benseñor, Eder Carlos da Rocha Quintão, Paulo A. Lotufo, Edna Regina Nakandakare
Publikováno v:
Bioscience Reports
It is controversial whether atherosclerosis is linked to increased intestinal cholesterol absorption or synthesis in humans. The aim of the present study was to relate atherosclerosis to the measurements of plasma markers of cholesterol synthesis (de