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Autor:
Susanne Herbst, Patrick A. Lewis
Publikováno v:
Biochemical Journal
Since the discovery of mutations in leucine-rich repeat kinase 2 (LRRK2) as an underlying genetic cause for the development of Parkinson's disease (PD) in 2004 (Neuron 44, 601–607; Neuron 44, 595–600), and subsequent efforts to develop LRRK2 kina
Publikováno v:
Biochemical Journal. 478:2179-2199
The regulation of proteasome activity is essential to cellular homeostasis and defects have been implicated in various disorders including Parkinson disease. The F-box protein FBXO7 has been implicated in early-onset parkinsonism and has previously b
Publikováno v:
Biochem J
Growth differentiation factor 8 (GDF8), a.k.a. myostatin, is a member of the larger TGFβ superfamily of signaling ligands. GDF8 has been well characterized as a negative regulator of muscle mass. After synthesis, GDF8 is held latent by a noncovalent
Publikováno v:
Biochemical Journal
NaCT/SLC13A5 is a Na+-coupled transporter for citrate in hepatocytes, neurons, and testes. It is also called mINDY (mammalian ortholog of ‘I'm Not Dead Yet’ in Drosophila). Deletion of Slc13a5 in mice leads to an advantageous phenotype, protectin
Autor:
Guo Xiaohui, Ke Cao, Jiarui Song, Xingyu Chen, Liu Chu, Wang Xinyu, Hua Lan, Songshu Xiao, Jing Yuan
Publikováno v:
Bioscience Reports
Minichromosome maintenance (MCM) family members are a group of genes involved in regulating DNA replication and cell division and have been identified as oncogenes in various cancer types. Several experimental studies have suggested that MCMs are dys
Autor:
Hampapathula Adimurthy Nagarajaram, Guruprasad Varma Konduru, Rajagopal Subramanyam, Ramurthy Gudla, Hari Parapatla, Dayananda Siddavattam, Elsin Raju Devadasu, Manjula Sritharan
Publikováno v:
Biochemical Journal. 477:2821-2840
Our previous studies have shown the existence of organophosphate hydrolase (OPH) as a part of the inner membrane associated Ton complex (ExbB/ExbD and TonB) of Sphingobium fuliginis. We now show its involvement in iron uptake by establishing direct i
Publikováno v:
Biochem J
The Biochemical journal, vol 477, iss 15
The Biochemical journal, vol 477, iss 15
RIT1 is a member of the Ras family of GTPases that direct broad cellular physiological responses through tightly controlled signaling networks. The canonical Ras GTPases are well-defined regulators of the RAF/MEK/ERK pathway and mutations in these ar
Publikováno v:
Biochemical Journal
Congenital dyserythropoietic anaemia (CDA) type I is a rare blood disorder characterised by moderate to severe macrocytic anaemia and hepatomegaly, with spongy heterochromatin and inter-nuclear bridges seen in bone marrow erythroblasts. The vast majo
Autor:
Dagmar Klostermeier, Arjan Kortholt, Jone Paesmans, Christian Galicia, Elise Daems, Wim Versées, Jan Steyaert, Linda Krause, Frank Sobott, Els Pardon, Margaux Leemans, Egon Deyaert
Publikováno v:
The biochemical journal
Biochemical Journal
Biochemical Journal, 477(7), 1203-1218. PORTLAND PRESS LTD
Biochemical Journal
Biochemical Journal, 477(7), 1203-1218. PORTLAND PRESS LTD
Mutations in the Parkinson's disease (PD)-associated protein leucine-rich repeat kinase 2 (LRRK2) commonly lead to a reduction of GTPase activity and increase in kinase activity. Therefore, strategies for drug development have mainly been focusing on
Publikováno v:
Bioscience Reports
Misfolded, pathological tau protein propagates from cell to cell causing neuronal degeneration in Alzheimer’s disease and other tauopathies. The molecular mechanisms of this process have remained elusive. Unconventional secretion of tau takes place