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Autor:
Maria Florencia Albertoni Borghese, Lucas Humberto Oronel, Maria Del Carmen Ortiz, Mónica Patricia Majowicz
Publikováno v:
Clinical Science. 136:1303-1339
The developmental origin of hypertension and renal disease is a concept highly supported by strong evidence coming from both human and animal studies. During development there are periods in which the organs are more vulnerable to stressors. Such per
Autor:
Karen T Elvers, Maia Kavanagh Williamson, Massimo Caputo, Darryl J. Hill, Paolo Madeddu, Andrew D. Davidson, Elisa Avolio, Imre Berger, Rachel Milligan, Kapil Gupta, David T Arnold, Michele Carrabba, Fergus Hamilton, Rebecca R. Foster, Kathleen M Gillespie, Monica Gamez, Antonio Paolo Beltrami
Publikováno v:
Avolio, E, Carrabba, M, Milligan, R, Kavanagh Williamson, M, Beltrami, A P, Gupta, K, Elvers, K T, Gamez, M, Foster, R R, Gillespie, K M, Hamilton, F W, Arnold, D T, Berger, I, Davidson, A D, Hill, D J, Caputo, M & Madeddu, P R 2021, ' The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147-receptor-mediated signalling : a potential non-infective mechanism of COVID-19 microvascular disease ', Clinical Science, vol. 135, no. 24, CS20210735, pp. 2667-2689 . https://doi.org/10.1042/CS20210735
Severe coronavirus disease 2019 (COVID-19) manifests as a life-threatening microvascular syndrome. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses the Spike (S) protein to engage with its receptors and infect host cells. To date
Autor:
Chad Whilding, Mohammad Bohlooly-Y, Laura A. B. Wilson, Alice E. Pollard, Lucy Penfold, David Carling, Patricia Wilson, Phillip J. Muckett
Publikováno v:
Clinical Science. 135:2393-2408
AMP-activated protein kinase (AMPK) plays a key role in the cellular response to low energy stress and has emerged as an attractive therapeutic target for tackling metabolic diseases. Whilst significant progress has been made regarding the physiologi
Autor:
Mingzhou Li, Jianmin Liu, Weixiang He, Daoquan Liu, Xun Fu, Ping Chen, Michael E. DiSanto, Xinhua Zhang, Xueneng Zhang, Xinghuan Wang, Guang Zeng, Yan Li
Publikováno v:
Clinical Science. 135:1591-1608
Benign prostatic hyperplasia (BPH) is a quite common illness but its etiology and mechanism remain unclear. Neural epidermal growth factor-like like 2 (NELL2) plays multifunctional roles in neural cell growth and is strongly linked to the urinary tra
Publikováno v:
Clin Sci (Lond)
Pregnancies complicated by severe, early-onset fetal growth restriction with abnormal Doppler velocimetry (FGRadv) have a sparse villous vascular tree secondary to impaired angiogenesis. As endothelial cell (EC) and stromal matrix interactions are ke
Autor:
Xin Chen, Xiao-Feng Li, Jun Li, Dong-Qing Wu, Hua Wang, Hai-Di Li, Lei Yang, Na-Na Yin, Cheng Huang, Xiao-Ming Meng, Ying-Yin Sun
Publikováno v:
Clinical Science. 135:1213-1232
Background and aims: Alcoholic fatty liver (AFL) is an early form of alcoholic liver disease (ALD) that usually manifests as lipid synthesis abnormalities in hepatocytes. β-arrestin2 (Arrb2) is involved in multiple biological processes. The present
Autor:
Julie Chao, Hui-Yao Lan, Ye Li, Sarah W.Y. Lok, Xiao-Ru Huang, Wai Han Yiu, Kam Wa Chan, James Hok-Leung Tsu, Kar Neng Lai, Sydney C.W. Tang, Loretta Y.Y. Chan, Joseph Leung
Publikováno v:
Clinical Science. 135:429-446
Kallistatin is a multiple functional serine protease inhibitor that protects against vascular injury, organ damage and tumor progression. Kallistatin treatment reduces inflammation and fibrosis in the progression of chronic kidney disease (CKD), but
Autor:
Yan Shi, Jizhuang Wang, Dan Liu, Peilang Yang, Yan Liu, Xiong Zhang, Min Gao, Tianyi Yu, Jie Zhang
Publikováno v:
Clinical Science (London, England : 1979)
Acute lung injury (ALI) is the leading cause of death in sepsis patients. Exosomes participate in the occurrence and development of ALI by regulating endothelial cell inflammatory response, oxidative stress and apoptosis, causing serious pulmonary va
Autor:
Qiaofeng Qian, Xinhua Zhang, Xun Fu, Mingzhou Li, Qian Wang, Guang Zeng, Xiao Wang, Daxing Zhan, Daoquan Liu, Jianmin Liu, Weixiang He, Michael E. DiSanto, Xinghuan Wang, Ping Chen, Yan Li
Publikováno v:
Clinical Science. 135:167-183
Benign prostatic hyperplasia (BPH) is a common disease among aging males with the etiology remaining unclear. We recently found myosin II was abundantly expressed in rat and cultured human prostate cells with permissive roles in the dynamic and stati
Autor:
Mariana Rodrigues Davanso, Cátia Lira do Amaral, Maria Lúcia Corrêa-Giannella, Dhêmerson Souza de Lima, Eicke Latz, Niels Olsen Saraiva Camara, Vinícius Nunes Cordeiro Leal, Tarcio Teodoro Braga, Amanda Rabello Crisma, Carl Christian Kolbe, José Alexandre Marzagão Barbuto, Thiago A. Patente, Alessandra Pontillo, Laureane Nunes Masi, Rui Curi, Mario A.R. Lauterbach
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease characterized by insulin-producing pancreatic β-cell destruction and hyperglycemia. While monocytes and NOD-like receptor family-pyrin domain containing 3 (NLRP3) are associated with T1D