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Autor:
K A, Deynichenko, K G, Ptitsyn, S P, Radko, L K, Kurbatov, I V, Vakhrushev, I V, Buromski, S S, Markin, A I, Archakov, A V, Lisitsa, E A, Ponomarenko
Publikováno v:
Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry. 16:318-327
The analysis of cytochrome P450 transcripts was carried out by the nanopore sequencing in liver tissue samples of three donors and HepG2 line cells. It has been demonstrated that direct mRNA sequencing with a MinION nanopore sequencer (Oxford Nanopor
Autor:
Veronika Ivanova-Radkevich
Publikováno v:
Biochemistry (Moscow). 87:1226-1242
The method of photodynamic therapy for treatment of malignant neoplasms is based on the selective of accumulation of photosensitizers in the tumor tissue. Insufficient selectivity of photosensitizers in relation to pathologically altered tissues and
Publikováno v:
Biochemistry (Moscow). 87:1219-1225
Abstract Lung cancer (LC), one of the most common malignant neoplasms, is the leading cause of high cancer mortality worldwide. Smoking is a risk factor for almost all histological types of LC. Benzo[a]pyrene (BaP), one of the main constituents of to
Publikováno v:
Biochemistry (Moscow). 87:1199-1205
Lung and colorectal cancers are the most common types of cancer characterized by a poor prognosis and a high mortality rate. Mutations in the genes encoding components of the main intra- and extracellular signaling pathways, in particular the NOTCH1
Autor:
Galina Yu, Riznichenko, Natalya E, Belyaeva, Ilya B, Kovalenko, Taras K, Antal, Sergei N, Goryachev, Aleksei S, Maslakov, Tatiana Yu, Plyusnina, Vladimir A, Fedorov, Sergei S, Khruschev, Olga V, Yakovleva, Andrew B, Rubin
Publikováno v:
Biochemistry (Moscow). 87:1065-1083
Summarized results of investigation of regulation of electron transport and associated processes in the photosynthetic membrane using methods of mathematical and computer modeling carried out at the Department of Biophysics, Faculty of Biology, Lomon
Publikováno v:
Biochemistry (Moscow). 87:1021-1034
Skeletal muscles mainly contribute to the emergence of insulin resistance, impaired glucose tolerance and the development of type 2 diabetes. Molecular mechanisms that regulate glucose uptake are diverse, including the insulin-dependent as most impor
Publikováno v:
Biochemistry (Moscow). 87:832-838
Hypertrophic cardiomyopathy (HCM) is a hereditary heart disease caused by mutations in the sarcomere genes, which is accompanied by myocardial fibrosis leading to progressive heart failure and arrhythmias. Recent studies suggest that the HCM developm
Publikováno v:
Doklady Biochemistry and Biophysics. 505:137-140
Abstract A lot of long non-coding RNAs (lncRNAs) are expressed in human cells in a number of transcripts of different lengths and composition of exons. In case of cancer-associated lncRNAs, an actual task is to determine their specific isoforms, sinc
Publikováno v:
Biochemistry (Moscow). 87:689-701
Alzheimer's disease is the most common age-related progressive neurodegenerative disorder of brain cortex and hippocampus leading to cognitive impairment. Accumulation of extracellular amyloid plaques and intraneuronal neurofibrillary tangles are bel
Autor:
Irina, Gostimskaya
Publikováno v:
Biochemistry (Moscow). 87:777-788
The development of a method for genome editing based on CRISPR-Cas9 technology was awarded The Nobel Prize in Chemistry in 2020, less than a decade after the discovery of all principal molecular components of the system. For the first time in history