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Autor:
Andrijana Lazic, Natasa Anastasov, Danijela Stanisavljevic Ninkovic, Stefan Lazic, Milena Stevanovic, Natasa Kovacevic-Grujicic, Vanda Balint
Publikováno v:
Biochemistry (Moscow). 86:1434-1445
Astrocytes are the main homeostatic cells in the central nervous system (CNS) that provide mechanical, metabolic, and trophic support to neurons. Disruption of their physiological role or acquisition of senescence-associated phenotype can contribute
Publikováno v:
Biochemistry (Moscow). 86:1377-1387
Sorting nexin 10 (SNX10) induces formation of vacuoles participating in the endosome morphogenesis in mammalian cells, but the key amino acids involved in this function have not been fully identified. In this study, point mutations were introduced to
Publikováno v:
Biochemistry (Moscow). 86:1352-1367
The review discusses the role of metabolic disorders (in particular, insulin resistance) in the development of age-related diseases and normal aging with special emphasis on the changes in postmitotic cells of higher organisms. Caloric restriction he
Autor:
Darya O. Kuzmina, Ekaterina V. Nekrasova, Vladimir S. Shavva, Igor V. Kudriavtsev, Ekaterina E. Larionova, Katerina V. Danko, S. V. Orlov
Publikováno v:
Biochemistry (Moscow). 86:1201-1213
Apolipoprotein A-I (ApoA-I) is a key component of reverse cholesterol transport in humans. In the previous studies, we demonstrated expression of the apoA-I gene in human monocytes and macrophages; however, little is known on the regulation of the ap
Autor:
Pavel Ivanov
Publikováno v:
Biochemistry (Moscow). 86:1044-1052
Messenger RNA is complexed with proteins throughout its life cycle. The first mRNA-containing particles of non-ribosomal nature, named informosomes, were discovered in cytoplasmic extracts of fish embryos by the laboratory of Alexander Spirin, and la
Autor:
S. A. Levitskii, Darya G. Krasavina, Maria V. Baleva, Piotr Kamenski, Uliyana E. Piunova, I. V. Chicherin
Publikováno v:
Biochemistry (Moscow). 86:1151-1161
Despite its similarity to protein biosynthesis in bacteria, translation in the mitochondria of modern eukaryotes has several unique features, such as the necessity for coordination of translation of mitochondrial mRNAs encoding proteins of the electr
Autor:
N. P. Bondar, Vasiliy V. Reshetnikov
Publikováno v:
Biochemistry (Moscow). 86:613-626
Abstract Stress negatively affects processes of synaptic plasticity and is a major risk factor of various psychopathologies such as depression and anxiety. HOMER1 is an important component of the postsynaptic density: constitutively expressed long is
Autor:
Alexey E Medvedev, Olga A Buneeva
Publikováno v:
Biochemistry (Moscow). 86:627-640
DJ-1, also known as Parkinson's disease protein 7, is a multifunctional protein ubiquitously expressed in cells and tissues. Interacting with proteins of various intracellular compartments, DJ-1 plays an important role in maintaining different cellul
Autor:
V.V. Ashapkin, G. V. Morgunova, T S Putyatina, Vladimir P. Skulachev, G. A. Shilovsky, A. V. Seliverstov, Alexander V. Markov, E.V. Sorokina
Publikováno v:
Biochemistry. Biokhimiia
This review discusses genetic and molecular pathways that link circadian timing with metabolism, resulting in the emergence of positive and negative regulatory feedback loops. The Nrf2 pathway is believed to be a component of the anti-aging program r
Autor:
Elizaveta I Shestoperova, Vladimir N. Uversky, Nikolay S. Ilyinsky, Semen V. Nesterov, Alexander V. Fonin, Valentin Gordeliy
Publikováno v:
Biochemistry (Moscow). 86:275-289
Aging is a prime systemic cause of various age-related diseases, in particular, proteinopathies. In fact, most diseases associated with protein misfolding are sporadic, and their incidence increases with aging. This review examines the process of pro