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Autor:
N. P. Bondar, Vasiliy V. Reshetnikov
Publikováno v:
Biochemistry (Moscow). 86:613-626
Abstract Stress negatively affects processes of synaptic plasticity and is a major risk factor of various psychopathologies such as depression and anxiety. HOMER1 is an important component of the postsynaptic density: constitutively expressed long is
Autor:
Maria S. Shutova, Tatyana Svitkina
Publikováno v:
Biochemistry (Moscow). 83:1459-1468
Various forms of cell motility critically depend on pushing, pulling, and resistance forces generated by the actin cytoskeleton. Whereas pushing forces largely depend on actin polymerization, pulling forces responsible for cell contractility and resi
Publikováno v:
Biochemistry (Moscow). 83:1477-1488
Cell senescence is an artificially reversible condition activated by various factors and characterized by replicative senescence and typical general alteration of cell functions, including extra-cellular secretion. The number of senescent cells incre
Autor:
E. N. Grigoryan
Publikováno v:
Biochemistry (Moscow). 83:1318-1331
Modern achievements in the understanding of tissue regeneration, identification of endogenous cell sources for regeneration, and development of approaches for induction and differentiation of pluripotent stem cells have open broad prospects for regen
Publikováno v:
Biochemistry (Moscow). 83:1380-1387
Lymphocyte phosphatase-associated phosphoprotein (LPAP) is a molecular partner of CD45 phosphatase that plays a key role in the regulation of antigen-specific activation of lymphocytes. The functions of LPAP still remain unknown. We believe that stud
Publikováno v:
Biochemistry (Moscow). 83:1289-1298
CDKN2A is one of the most studied tumor suppressor genes. It encodes the p16-INK4a protein that plays a critical role in the cell cycle progression, differentiation, senescence, and apoptosis. Mutations in CDKN2A or dysregulation of its functional ac
Autor:
M. S. Bochkova, M. B. Rayev, P. V. Khramtsov, V. P. Timganova, K. A. Fomicheva, V. A. Chereshnev, S. A. Zamorina
Publikováno v:
Doklady Biological Sciences. 482:210-213
The effect of native α-fetoprotein (AFP) on the conversion of naïve T-helpers into central memory T-cells (TCM) and effector subpopulations of the preterminally differentiated (TEM) and terminally differentiated (TEMRA) memory T-cells was studied.
Autor:
V. V. Simonova, Sergey N. Illarioshkin, Leonid G. Khaspekov, A S Vetchinova, E. V. Novosadova
Publikováno v:
Biochemistry (Moscow). 83:1040-1045
The prevalent form of familial parkinsonism is caused by mutations in the LRRK2 gene encoding for the mitochondrial protein kinase. In the review, we discuss possible causes of appearance of tetraploid cells in neuronal precursors obtained from induc
Autor:
V. Y. Brodsky
Publikováno v:
Biochemistry (Moscow). 83:890-906
Biochemical mechanisms for the orchestration of cell populations are discussed in view of direct cell-cell interactions and composition of the intercellular medium. In our works of the last 20 years, we used circahoralian (ultradian) rhythm of protei
Autor:
K T Turpaev
Publikováno v:
Biochemistry (Moscow). 83:863-873
Translation factor eIF5A participates in protein synthesis at the stage of polypeptide chain elongation. Two eIF5A isoforms are known that are encoded by related genes whose expression varies significantly in different tissues. The eIF5A1 isoform is