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Publikováno v:
The Journal of Physiological Sciences. 58:249-261
We investigated the pivotal roles of glucose and its transporter in the regulation of mechanical activity of isolated rat thoracic ducts and then examined whether mitochondrial ATP-sensitive K(+) channels (mitoK(ATP)) are involved in those responses.
Publikováno v:
The Japanese Journal of Physiology. 52:561-572
Changes in the volume of rat alveolar type II cells (AT-II cells) induced by terbutaline, a beta(2)-agonist, were measured using video-enhanced contrast microscopy. The changes consisted of three phases: initial cell shrinkage, cell swelling, and gra
Publikováno v:
The Japanese Journal of Physiology. 52:531-539
We investigated the mechanism of alpha(1)-adrenoceptor stimulation on the myofibrillar Ca(2+) responsiveness at steady-state in intact rat ventricular myocytes. We produced tetanus, and an instantaneous plot of [Ca(2+)](i) vs. cell length (Ca-L traje
Autor:
Susumu Sakata, Yoshiro Yoshikawa, Nobuoki Tabayashi, Hiromi Misawa, Miyako Takaki, Takehisa Abe, Shigeki Taniguchi, Kobayashi S, Chikako Takenaka
Publikováno v:
The Japanese Journal of Physiology. 52:163-171
The aim of the present study was to compare the oxygen (O(2)) cost of left ventricular (LV) contractility (equivalent maximal elastance; eEmax, an index for contractility) for dobutamine (a beta-receptor stimulant) with that for calcium (Ca(2+)) in n
Publikováno v:
The Japanese Journal of Physiology. 50:67-76
Although the importance of mechanical stress on bone metabolism is well known, the intracellular mechanisms involved are not well understood. To evaluate the role of mechanical stress on osteoclastic function, we investigated the effects of membrane
Publikováno v:
The Japanese Journal of Physiology. 49:335-343
The effects of muscarinic and beta-adrenergic agonists on Cl(-) currents in acinar cells were investigated to clarify their role in the regulation of fluid secretion in rat perfused submandibular glands. Additions of isoproterenol (IPR) at 10(-8) to
Contribution of Na+/Ca2+ Exchanger in Maintaining (Ca2+)c at a Stable State in Rat Pancreatic Islets
Publikováno v:
The Japanese Journal of Physiology. 46:473-480
The effects of lowering extracellular Na+ concentration [Na+]o, on cytosolic Ca2+ concentration, [Ca2+]c were examined by a microfluorimetric method using fura-2 in perifused preparations of isolated rat pancreatic islets. The total replacement of ex
Autor:
Noritaka Kamimura, Sechiko Suga, Yasue Fukushi, Akinori Nishiyama, Yoshihisa Mio, Makoto Wakui, J. Wada
Publikováno v:
The Japanese Journal of Physiology. 45:1071-1085
In order to examine whether Ca2+ entry is directly involved in controlling exocrine secretion, the Ca(2+)-activated Cl- currents were recorded in single and clusters of rat submandibular gland cells using the whole-cell patch-clamp method. Extracellu
Publikováno v:
The Japanese Journal of Physiology. 42:415-430
The mechanisms of norepinephrine-induced membrane responses in isolated hepatocytes from guinea-pigs and rats were compared using the suction-pipette, patch-clamp method, and intracellular Ca2+ concentration ([Ca2+]i) was measured using the Ca2+ fluo
Autor:
Keiichi Yoshimura, Eriko Nezu
Publikováno v:
The Japanese Journal of Physiology. 41:443-459
Isolated parotid acinar cells were perifused in small columns by embedding them in Bio-Gel P-2 beads as an inert supporting matrix, and the effect of carbamylcholine, substance P, and isoproterenol on the rate of amylase release was examined by measu