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Autor:
Kazuhiko Shibata, Takahiro Niimura, Mami Uchida, Noriaki Hidaka, Yoshihisa Kitamura, Kenshi Takechi, Keisuke Ishizawa, Hiroyuki Namba, Mamoru Tanaka, Hitoshi Kawazoe, Hiromu Kawasaki, Soichiro Ushio, Toshiaki Sendou, Yoshito Zamami, Akihiro Tanaka, Shingo Takatori, Hiroaki Araki
Publikováno v:
Biological and Pharmaceutical Bulletin. 45:226-234
Oxaliplatin (OXA) is used in chemotherapy for various cancer types and is associated with acute and chronic neurotoxicity. However, a preventive strategy for OXA-induced peripheral neuropathy (OIPN) and its underlying mechanism remain unclear. We exa
Autor:
Michiko Hanawa, Yohei Kawasaki, Takaaki Suzuki, Naoaki Rikihisa, Hirokazu Takatsuka, Nobuyuki Mitsukawa, Yuki Shiko, Itsuko Ishii
Publikováno v:
Biological and Pharmaceutical Bulletin. 45:42-50
We aimed to evaluate the efficacy and safety of propranolol gel at various concentrations with infantile hemangiomas after proliferative phases. We designed a single-center, randomized, double-blind, dose-dependent trial with placebo control and rand
Publikováno v:
Biological and Pharmaceutical Bulletin. 45:77-85
Cyclooxygenase (COX)-1-selective inhibitors have side effects such as itching and dryness of the skin. In this study, the degree of skin dryness and the onset mechanism of this condition were investigated by comparing the effects of three non-steroid
Publikováno v:
YAKUGAKU ZASSHI. 142:65-74
The crystallization of active pharmaceutical ingredients (APIs) in matrix-type transdermal patches has implications for the rate of drug absorption through the skin and patch adhesion strength. Therefore, the presence or absence and the degree of API
Autor:
Narandalai Danshiitsoodol, Masanori Sugiyama, Takemasa Sakaguchi, Masafumi Noda, Keishi Kanno
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1886-1890
A lactic acid bacterial strain, Lactobacillus plantarum SN35N, which has been isolated from the pear, secretes negatively charged acidic exopolysaccharide (EPS) to outside cells. We have previously found that the SN35N-derived acidic EPS inhibits the
Autor:
Kazuhiro Katayama, Ayane Nishihata
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1843-1850
Fms-like tyrosine kinase 3 (FLT3) and isocitrate dehydrogenase 1/2 (IDH1/2) mutations drive malignancy in acute myeloid leukemia (AML), which accounts for approximately 40% of AML cases. Treatment with FLT3 or IDH1/2 inhibitors is used for such patie
Autor:
Junzo Kamei
Publikováno v:
YAKUGAKU ZASSHI. 141:1333-1342
An increasing number of patients complain to medical institutions about a cough that persists for more than 8 weeks, namely chronic cough. The cough observed in patients with chronic cough is not responsive to conventional antitussive agents such as
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1894-1897
The lusitropic effect of quercetin was examined on isolated ventricular myocardial tissue preparations from normal and streptozotocin-induced diabetic mice. The time required for 90% relaxation of the myocardium, which was prolonged in the diabetic m
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1585-1592
Tyrosine kinase 2 (Tyk2) is a member of the Janus family of protein tyrosine kinases (Jaks). Tyk2 associates with interferon (IFN)-α, IFN-β, interleukin (IL)-6, IL-10, IL-12, and IL-23 receptors and mediates their downstream signaling pathways. Bas
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1781-1789
Dried terrestrial stems of Ephedra sinica are known as 'Ephedra herb.' The pharmacological effects are mainly related to two major ingredients, (-)-ephedrine and (+)-pseudoephedrine (total alkaloids which are defined in Japanese Pharmacopoeia, TA). I