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Autor:
Tatsuya Takagi, Masao Nasu, Chizuko Hattori, Steffen Amann, Yuko Shirakuni, Tsugumichi Sato, Carla M. Van Bennekom
Publikováno v:
YAKUGAKU ZASSHI. 135:1161-1168
Thalidomide was approved for the treatment of multiple myeloma in Japan under a risk management program, named TERMS, in 2008. Since then, we have been conducting a survey of the stakeholders to assess the effectiveness of TERMS. These surveys showed
Publikováno v:
Journal of Health Science. 57:72-77
We previously reported that novel polyselenodithiols are produced along with selenotrisulfide when a thiol (penicillamine) is reacted with selenite (H2SeO3). Here, we report the production of oligoselenodiglutathiones and their suppressive effects on
Publikováno v:
Journal of Health Science. 57:414-419
Strain differences in the induction of cytochrome P450 (CYP) affect drug actions and side effects. Strain differences in the induction of CYP are important to evaluate drug-drug interactions in CYPs. We clarified strain differences in the induction o
Autor:
Shutaro Katsurabayashi, Ai Nogami, Yuya Sakamoto, Michihiro Fujiwara, Masahiko Morita, Kenichi Mishima, Kaori Kubota, Katsunori Iwasaki, Masaki Nagao, Kotaro Takasaki, Koji Morishita
Publikováno v:
Journal of Health Science. 57:432-435
The memory enhancing effects of orally administered citidine-5-diphosphocholine or citicoline (CDPcholine) on memory impairment without neuronal cell death are still unknown. We investigated the effects of CDP-choline on memory disturbance induced by
Autor:
Hirofumi Hamano, Daisuke Kurihara, Nobuyuki Fukuishi, Nobuaki Matsui, Hayato Teruya, Kazue Kadota, Masaaki Akagi
Publikováno v:
JOURNAL OF HEALTH SCIENCE. 57:197-203
The spatial contact of immune cells is predominant machinery for the modulation of local inflammatory sites as much as humoral regulation is for inflammation. In this study, we investigated the role of mast cells in the regulation of invariant natura
Publikováno v:
Journal of Health Science. 57:153-163
It is generally known that many psychological factors, such as stress or insomnia, cause mental fatigue. However, the detailed mechanisms underlying mental fatigue have not been clarified. We speculated that mental fatigue may be caused by neuronal b
Autor:
Pazhanichamy Kalailingam, Kumaran Shanmugam, Aiswarya Devi Sekar, Eevera Tamilmani, Jeba Samuel Clement Samuel, Rajendran Kaliaperumal, Manjula Kesavan, Yogha Govindaraju, Priya Gandhirajan
Publikováno v:
JOURNAL OF HEALTH SCIENCE. 57:37-46
In this study, effect of an ethanolic extract from rhizome of Costus igneus were investigated on activity of following enzyme in liver, kidney, pancreas of streptozotocin (STZ) induced diabetic rats: carbohydrate metabolic enzymes such as glucokinase
Publikováno v:
Journal of Health Science. 57:204-209
Manganese (Mn) damages the central nervous system and causes Parkinson's disease (PD)-like syndrome called manganism. Abnormal accumulation of Mn and iron (Fe) is observed in the basal nuclei of patients with PD. Dopamine induces oxidative DNA damage
Autor:
Yasuhiro Uno, Ryo Koizumi, Hiroshi Yamazaki, Kazuhide Iwasaki, Norie Murayama, Chie Emoto, Masahiro Utoh
Publikováno v:
Journal of Health Science. 57:164-170
Cynomolgus monkeys [Macaca fascicularis (mf)] are widely used to determine pharmacokinetics and toxicological potential of many drug candidates as human models in the drug discovery and development. Cytochrome P450s (P450, CYP), one of the most impor
Autor:
Takayuki Izumo, Toshihiro Maekawa, Yoshinori Kitagawa, Masayuki Ida, Yuichi Furukawa, Yoshinobu Kiso
Publikováno v:
Journal of Health Science. 57:304-310
Lactobacillus pentosus S-PT84, which was isolated from Kyoto pickles, enhances splenic natural killer (NK) cell activity, increases IgA production from Peyer’s patch cells and has high T-helper 1 (Th1) cytokine and type 1interferon-inducing activit