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Autor:
Tatsuya Takagi, Masao Nasu, Chizuko Hattori, Steffen Amann, Yuko Shirakuni, Tsugumichi Sato, Carla M. Van Bennekom
Publikováno v:
YAKUGAKU ZASSHI. 135:1161-1168
Thalidomide was approved for the treatment of multiple myeloma in Japan under a risk management program, named TERMS, in 2008. Since then, we have been conducting a survey of the stakeholders to assess the effectiveness of TERMS. These surveys showed
Publikováno v:
Journal of Health Science. 57:204-209
Manganese (Mn) damages the central nervous system and causes Parkinson's disease (PD)-like syndrome called manganism. Abnormal accumulation of Mn and iron (Fe) is observed in the basal nuclei of patients with PD. Dopamine induces oxidative DNA damage
Autor:
Tae Wha Kim, Yoo Sin Park, Dong-Sun Kim, Seong Jin Lee, Ju Seop Kang, Ok Hwa Jhee, Younghoon Kim, Shin-Hee Kim
Publikováno v:
Journal of Health Science. 57:378-383
Increased activity of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) has been implicated in the development of the metabolic syndromes by amplification of local glucocorticoid actions through regeneration of active glucocorticoid receptor. The
Publikováno v:
Journal of Health Science. 57:142-152
We researched the preventive and therapeutic activities of the extract of Ramulus Mori (ERM) to observe its effects on collagen-induced arthritis (CIA) in mice and to explore the mechanisms of ERM in the treatment of rheumatoid arthritis (RA). We exa
Autor:
Fahaid Al-Hashem, Moshira Rateb, Ibrahim M. Ibrahim, Mohammed A. Dallak, Esma R. Isenovic, Nermeen Bastawy, Ismaeel Bin-Jaliah, Sanja Soskic, Mohamed A Haidara
Publikováno v:
Journal of Health Science
The present study was designed to investigate the effect of insulin on insulin resistance (IR), plasma adiponectin level and expression of adiponectin receptors 1 (AdipoR1) in obese and streptozotocin-induced type 2 diabetic rats. Male Sprague-Dowley
Autor:
Ranjitsinh V. Devkar, Ravirajsinh N. Jadeja, Menaka C. Thounaojam, Ansarullah, A. V. Ramachandran
Publikováno v:
Journal of Health Science. 56:92-98
The present study investigates effect of Sida rhomboidea ROXB .( S. rhomboidea ROXB., SR) on high fat diet (HFD) induced insulin resistance in C57BL/6J mice and the results obtained have been compared with mice fed with rosiglitazone (ROS). Changes i
Autor:
Mio Nakamoto, Gen-yuki Yamane, Tomohiro Yamauchi, Morio Tonogi, Hitoshi Ishigouoka, Takeshi Fukushima, Hideaki Ichiba, Yoichi Tanaka, Kazumichi Sato, Yoshio Inouye
Publikováno v:
Journal of Health Science. 56:684-689
TS-1 is an oral anticancer agent comprising three components: two biochemical modulators of 5-fluorouracil (5-FU) and tegafur (FT), a prodrug of 5-FU. TS-1 displays potent anti-tumor activity by maintaining effective 5-FU concentrations in serum for
Autor:
Fumihiko Kugawa, Akemichi Ueno
Publikováno v:
Journal of Health Science. 56:81-87
The multidrug treatment, CDF [cyclophosphamide (CPA), doxorubicin (DXR), and 5fluorouracil (5-FU)], is a common chemotherapy protocol for breast cancer. However, the molecular mechanisms underlying its toxicity for breast cancer cells remain unclear.
Publikováno v:
Journal of Health Science. 56:20-30
Diabetes enhances oxidative stress and exacerbates acute ischemic injury. Previous studies have demonstrated that infarct volumes were greater in diabetic animals caused by a transient cerebral ischemia as compared with non-diabetic animals. Ascorbic
Publikováno v:
Journal of Health Science. 56:326-330
The demethylation of methylmercury (MeHg) was investigated in human neuroblastoma, glioblastoma and liver cells. In the three cell lines, MeHg uptake reached a plateau within 24 hr after MeHg exposure while the cellular inorganic Hg levels increased