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Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1323-1331
Disulfiram (DSF), an old anti-alcoholism drug, has emerged as a candidate for drug repurposing in oncology. In exploratory studies on its therapeutic effects, we unexpectedly discovered that DSF increased the phosphorylation of SRC, a proto-oncogene
Autor:
Masahiro Ono, Hideo Saji, Yoichi Shimizu, Hiroyuki Watanabe, Ning Ding, Takeshi Namita, Kohei Sano, Tsuyoshi Shiina
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1859-1866
Surgery remains one of the main treatments of cancer and both precise pre- and intraoperative diagnoses are crucial in order to guide the operation. We consider that using an identical probe for both pre- and intra-operative diagnoses would bridge th
Autor:
Tsumugi Eifuku, Noriaki Nagai, Tomonori Hayashi, Hinako Kawaguchi, Atsufumi Kawabata, Hiroshi Matsuoka
Publikováno v:
Chemical and Pharmaceutical Bulletin. 68:879-884
The percutaneous absorption of a fentanyl (FEN)-patch is affected by various external factors including the volume of sebum secretion, which causes changes in the skin surface environment. In this study, we prepared a lard-based sebum-like secretion
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:1846-1853
As alveolar macrophages are attractive targets for the treatment of tuberculosis, effective methods for delivery to alveolar macrophages are under development. We investigated a pulmonary formulation for the efficient delivery of high water-soluble d
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:1226-1229
Flecainide, an anti-arrhythmic drug, undergoes renal excretion through active renal tubular secretion in addition to passive glomerular filtration. The contribution of renal uptake and efflux transporters in active renal tubular secretion of flecaini
Publikováno v:
YAKUGAKU ZASSHI. 139:989-992
The molecular basis underlying the conversion of normal prion protein (PrPC) into abnormal prion protein (PrPSc) has not been fully elucidated. The protein-misfolding cyclic amplification (PMCA) technique, which can amplify PrPSc in vitro with the us
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:703-711
Cigarette smoke is a well-known strong risk factor for inducing airway hyperreactivity (AHR), but the underlying molecular mechanisms are not fully understood. In the present study, mouse in-vivo and in-vitro models were used to study effects of dime
Autor:
Nao Shigematsu, Daisuke Kobayashi, Takehiro Kawashiri, Anna Miyagi, Takao Shimazoe, Shiori Shimizu
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:638-644
Oxaliplatin has been used as a first choice for colorectal, gastric and pancreatic cancer, but it induces peripheral neuropathies. Dimethyl fumarate (DMF) is an oral drug for multiple sclerosis with neuroprotective effects on oxidative stress. Using
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:501-506
The mechanism underlying the increased pharmacological effects of phenobarbital in rats with glycerol-induced acute renal failure (ARF) was examined. In the experiments, a surgical cannula was inserted in the lateral ventricle of the rats for phenoba
Autor:
Hidetaka Akita, Mitsutoshi Yoneyama, Kota Tange, Takara Ohto, Yuta Nakai, Hiroki Tanaka, Manami Konishi, Hiroki Yoshioka, Koji Onomoto
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:299-302
While the use of in vitro-transcribed mRNA (IVT-mRNA) in therapeutics is a rapidly expanding area, the transfection of the exogenous IVT-mRNA is accompanied by a risk of immune activation. This immunological defense mechanism suppresses cellular tran