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Autor:
Tsumugi Eifuku, Noriaki Nagai, Tomonori Hayashi, Hinako Kawaguchi, Atsufumi Kawabata, Hiroshi Matsuoka
Publikováno v:
Chemical and Pharmaceutical Bulletin. 68:879-884
The percutaneous absorption of a fentanyl (FEN)-patch is affected by various external factors including the volume of sebum secretion, which causes changes in the skin surface environment. In this study, we prepared a lard-based sebum-like secretion
Autor:
Nao Shigematsu, Daisuke Kobayashi, Takehiro Kawashiri, Anna Miyagi, Takao Shimazoe, Shiori Shimizu
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:638-644
Oxaliplatin has been used as a first choice for colorectal, gastric and pancreatic cancer, but it induces peripheral neuropathies. Dimethyl fumarate (DMF) is an oral drug for multiple sclerosis with neuroprotective effects on oxidative stress. Using
Autor:
Ghassan Abu Sheikha, Mustafa S Aboumair, Samah A. Ata, Dima A. Sabbah, Majdi M. Bkhaitan, Tariq Al-Qirim, Kamal Sweidan, Ghassan Shattat, Samah A Ala, Haneen M Abuzaid, Suhair H Jasim
Publikováno v:
Chemical and Pharmaceutical Bulletin. 66:953-958
A new series of imidazole-5-carboxamide derivatives were prepared and tested for their anti-hyperlipidemic activity in Triton-WR-1339-induced hyperlipidemic Wistar rats. The purpose of this research was to improve benzophenone carboxamides water solu
Publikováno v:
Biological & Pharmaceutical Bulletin. 40:1361-1365
There have been few reports concerning to the drug-drug interactions (DDIs) with OTC drugs although an increase in the use of OTC drugs in recent years. This current study was conducted to clarify the DDIs through CYP3A inhibition by oxethazaine (OXZ
Publikováno v:
Biological & Pharmaceutical Bulletin. 40:1566-1571
The objective of this study was to evaluate the interactions between various drugs and aojiru (green juice), a popular health food in Japan, using a simple centrifugation method. The mixture of drug solution and aojiru suspension was gently shaken an
Autor:
Takahiro Yoshizawa, Kiyoshi Matsumoto, Shin Shimada, Takayuki Shindo, Takeshi Tokudome, Sho Takizawa
Publikováno v:
Biological & Pharmaceutical Bulletin. 39:737-746
Doxorubicin (DOX) is one of the best known anticancer drugs, and is used in the treatment of lymphoma, lung cancer, stomach cancer, and a number of other cancers. However, DOX has some serious side effects, the worst being lethal heart failure. Occas
Autor:
Noritaka Nakamichi, Takuya Shimizu, Yusuke Masuo, Ai Kijima, Saki Takahashi, Tomoko Sugiura, Takahiro Ishimoto, Yukio Kato
Publikováno v:
Biological & Pharmaceutical Bulletin. 38:774-780
5-Aminosalicylic acid (5-ASA) is an orally administered therapeutic agent for inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease. We hypothesized that the absorption of 5-ASA is mediated by the polyspecific carnitine/organic
Autor:
Shuang-Yong Sun, Lin Chen, Jun-Jun Zhou, Zheng Deng, Zhan-Cheng Gao, Xiao-Ping Pu, Hui-Qi Ge, Zhi-Peng Zhu, Dong-Ying Wu, Liangren Zhang
Publikováno v:
Biological and Pharmaceutical Bulletin. 36:1348-1355
Airway hyperresponsiveness (AHR) and airway inflammation are key pathophysiological features of many respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). To evaluate the treatment responses of procaterol and CD38 inh
Autor:
Osamu Hosoya, Yuya Egawa, Rina Yajima, Kazuhiko Juni, Chihiro Suzuki, Toshinobu Seki, Shinji Oshima
Publikováno v:
Biological and Pharmaceutical Bulletin. 35:203-209
Studies on drug disposition in inflamed skin are important for safe and effective application of topical drugs. Here, the absorption of flurbiprofen (FP) through inflamed skin was examined in vivo and in a skin-mimicking artificial model system. The
Publikováno v:
Chemical and Pharmaceutical Bulletin. 60:300-305
We proposed an in vitro/in vivo/in silico method for evaluating the clinical performance of matrix type transdermal therapeutic systems (TTSs). This method is based on the following four approaches: (1) drug release experiment, (2) in vitro penetrati