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Autor:
Noritaka Nakamichi, Takuya Shimizu, Yusuke Masuo, Ai Kijima, Saki Takahashi, Tomoko Sugiura, Takahiro Ishimoto, Yukio Kato
Publikováno v:
Biological & Pharmaceutical Bulletin. 38:774-780
5-Aminosalicylic acid (5-ASA) is an orally administered therapeutic agent for inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease. We hypothesized that the absorption of 5-ASA is mediated by the polyspecific carnitine/organic
Publikováno v:
Chemical and Pharmaceutical Bulletin. 60:300-305
We proposed an in vitro/in vivo/in silico method for evaluating the clinical performance of matrix type transdermal therapeutic systems (TTSs). This method is based on the following four approaches: (1) drug release experiment, (2) in vitro penetrati
Publikováno v:
YAKUGAKU ZASSHI. 130:1353-1359
For the purpose of enhancing the anticancer potency of docetaxel, a novel excipient, cholesterol-PEG-folate (α-(3.beta) cholest-5-en-3-ω-folic acid-poly (oxy-1, 2-ethanediyl)), was synthesized and used for the preparation of liposomes (folate-conju
Publikováno v:
Biological and Pharmaceutical Bulletin. 33:1183-1191
The aim of this study was to elucidate the efficacy of combination therapy with irinotecan and amrubicin for lung cancer and the influence of administration schedule in a xenograft mouse model and human cancer cell culture. We investigated the antitu
Publikováno v:
Biological and Pharmaceutical Bulletin. 32:640-645
The structural similarity between papaverine and berberine, a known inhibitor of human protein tyrosine phosphatase 1B (h-PTP 1B), prompted us to investigate the potential of papaverine as h-PTP 1B inhibitor. The investigation included simulated dock
Autor:
Rong Rong Guo, Xue Qing Wang, Qiang Zhang, Ji Hui Zhao, Wan Liang Lu, Hua Zhang, Yang Liu, Xuan Zhang, Jian Cheng Wang
Publikováno v:
Biological and Pharmaceutical Bulletin. 31:696-702
The metastasis of tumor cells is one of the major obstacles to successful clinical therapy. A treatment strategy by incorporating a specific inhibitor of thrombin, recombinant hirudin with stealthy liposomal vinblastine, was used in this study for in
Autor:
Yosuke Masui, Mieko Ohnuki, Shinya Suzuki, Masao Sato, Toyoki Mori, Katsuyuki Nakajima, Goro Miyakoda
Publikováno v:
Biological and Pharmaceutical Bulletin. 30:791-794
In this study, we examined the effect of Cilostazol to induce metallothionein (MT) in vivo and in vitro. Intraperitoneal injection of Cilostazol increased the expression of both MT-1 and MT-2 mRNA and total MT protein in the mouse liver. Cilostazol a
Autor:
Jasna Horvat Mikulcić, Snjezana Zidar, Zdravka Knezevic, Lara Krizmanić, Dragica Rausl, M. Zahirul I. Khan, Ruzica Zanoski, Maja Eskinja, Boris Mildner
Publikováno v:
Biological and Pharmaceutical Bulletin. 27:1630-1635
Loratadine was studied both in vitro and in vivo (in healthy humans) to classify it according to the Biopharmaceutics Classification System (BCS) in order to gain more understanding of the reasons for its highly variable nature with respect to plasma
Autor:
Tomoyuki Matsuda, Kazuo Noguchi, Mariko Saito, Haruko Masumiya, Hikaru Tanaka, Mie Ito, Naoko Iida-Tanaka, Koki Shigenobu
Publikováno v:
Biological and Pharmaceutical Bulletin. 27:131-135
The effects of terfenadine, an antiallergic drug also known for its QT-prolonging and arrhythmogenic activities, on the action potential of isolated myocardial tissue preparations from rabbits were examined with microelectrode techniques. In the Purk
Publikováno v:
Biological and Pharmaceutical Bulletin. 26:69-72
A matrix-type transdermal therapeutic system was developed for treating diseases of the eye where it is difficult for drug molecules to reach with conventional topical instillation. Prednisolone was employed as a model drug. An in vivo study using ra