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Publikováno v:
Biological and Pharmaceutical Bulletin. 33:1360-1363
Ligusticum wallichii is an herb widely used to treat vascular disorders in Asian countries, and tetramethylpyrazine (TMP) has been identified as one of its vasorelaxant active components. This study was performed to examine the endothelium-independen
Autor:
José Raúl Medina, Adriana Miriam Domínguez-Ramírez, Marcela Hurtado, Alba Jady Delgadillo, Alma Rosa Cortés, Kazuko Aoki
Publikováno v:
Biological and Pharmaceutical Bulletin. 29:1186-1190
The antispasmodic activity of extracts from the aerial parts of Buddleja scordioides and Buddleja perfoliata (family: Scrophulariaceae) was studied on isolated tissue preparations from rabbit and guinea pig intestine. The chloroformic extract from th
Publikováno v:
Biological and Pharmaceutical Bulletin. 28:1450-1454
This study was designed to investigate the effects of the aqueous ethanol extract of Astragalus membranaceus BUNGE (Leguminosae) on rat thoracic aorta. Isometric tension was recorded in response to drugs in organ bath. In endothelium-intact aortic ri
Autor:
Tokiko Aikawa, Tadashi Ishii, Koki Shigenobu, Ryo-ichi Fujisaki, Yusuke Miyamoto, Yoshino Tanaka, Hikaru Tanaka, Toru Kawanishi, Wataru Hirayama
Publikováno v:
Biological and Pharmaceutical Bulletin. 25:323-326
Effects of Mn2+ on isolated guinea pig ventricular myocardia were examined. In isolated papillary muscles, Mn2+ produced a transient decrease in contractile force followed by a late sustained augmentation. Mn2+ markedly increased the amplitude of pos
Publikováno v:
Biological and Pharmaceutical Bulletin. 23:1357-1362
The in vitro permeation of three diclofenac salts--diclofenac sodium (DFS), diclofenac potassium (DFP) and diclofenac diethylammonium (DFD)-across skin by both passive and iontophoretic transport were investigated. Various skin types were used as the
Publikováno v:
Biological and Pharmaceutical Bulletin. 31:1813-1815
We examined the effect of 1-amino-3,5-dimethyladamantane (memantine) and (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801) on the inhibition of [(3)H]MK-801 binding to crude synaptic membranes of rat forebrains in the absence
Autor:
Ken-ichi Sasaki, Kimiko Koiwai, Masayasu Ozaki, Minoru Sasaki, Masaaki Ishikawa, Yoshio Takayanagi
Publikováno v:
Journal of Pharmacobio-Dynamics. 15:377-385
The effect of selenium administered acutely or chronically on the hepatic microsomal drug-metabolizing system has been investigated in mice. After 72 h following acute administration of selenium (7.5 mg/kg, i.p.), there was a significant inhibition o
Publikováno v:
Biological and Pharmaceutical Bulletin. 18:1790-1792
Sodium nonivamide acetate (SNA) is a newly synthetic analogue of capsaicin which produces no overt pungent sensation or irritation. In this present study, the effects and roles of penetration enhancers for SNA through rat skin were investigated by in
Publikováno v:
Biological and Pharmaceutical Bulletin. 16:431-433
Elevation of intracellular sodium ion concentration in human erythrocyte induced by the cardiac glycoside, proscillaridin, and its four derivatives was measured using 23Na NMR spectrometry. In this examination, there was a significant correlation bet
Publikováno v:
Chemical and Pharmaceutical Bulletin. 39:1320-1322
The in vivo effect of nicardipine, a well-known calcium antagonist, on microsomal omega-oxidation of laurate in clofibrate-treated rat liver was studied. The 15.3-fold induction of the activity by 2 weeks administration of 0.25% clofibrate in the die