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Publikováno v:
Journal of Pharmacobio-Dynamics. 9:473-478
The effects of bile salts on the calcium movements and the electrical activity of the guinea-pig taenia coli were investigated and compared with those of papaverine in order to explore the mechanisms of their spasmolytic action. Four bile salts, deox
Publikováno v:
Journal of Pharmacobio-Dynamics. 5:877-885
The effects of caffeine and thymol on the release of calcium from sarcoplasmic reticulum (SR) of mechanically skinned fibers isolated from semitendinosus muscle of frog, Xenopus laevis, are studied. Calcium release caused by caffeine is composed of t
Publikováno v:
Journal of Pharmacobio-Dynamics. 6:441-448
45Ca-loaded single smooth muscle cells were prepared from taenia coli of guinea pig. The cells were perfused continuously with physiological salt solution on membrane filter with pore size of 12 microns and radioactivity in the effluent was determine
Publikováno v:
Journal of Pharmacobio-Dynamics. 3:423-433
In the experiment on continuous perfusion of rat stomach in vivo, genipin inhibited only the gastric acid secretion induced by carbachol, but not by tetragastrin, or histamine. In the experiment on isolated organs, genipin showed a weak competitive a
Publikováno v:
Chemical and Pharmaceutical Bulletin. 24:3169-3177
Effects of various constituents of the perfusates on the sulfanilamide absorption were investigated using in situ recirculation perfusion method with the rat small intestine. Constituents employed were salts and chemical which had been used as compon
Autor:
Minoru Watanabe, Satoshi Narita
Publikováno v:
Journal of Pharmacobio-Dynamics. 5:285-294
Effects of calcium blockers and Mn on the mechanical response of the isolated rat iris sphincter and the dilator were investigated. The contraction of the sphincter in response to acetylcholine, the contraction of the dilator in response to norepinep
Autor:
Masayoshi Yamaguchi, Masaji Imase
Publikováno v:
Chemical and Pharmaceutical Bulletin. 35:4235-4240
The regulatory effect of calcitonin (CT) on succinate dehydrogenase in the hepatic mitochondria of rats was investigated. Administration of CT (80 MRC mU/100 g body weight) produced a significant increase in calcium content and a corresponding elevat
Autor:
Yoshio Aizawa, Takahiro Futami
Publikováno v:
Chemical and Pharmaceutical Bulletin. 24:193-199
The effect of surface-active agent on the active transport of sodium in the frog skin was studied. It was assumed that alkyldimethylbenzylammonium chloride (alkyl-DBAC) in 10-3M concentration inhibited the active transport of sodium accompanied with
Publikováno v:
Journal of Pharmacobio-Dynamics. 4:162-166
The inhibitory effect of bumetanide on the accumulation of p-aminohippurate (PAH) in rat kidney slices was investigated. Bumetanide increased the Km value for PAH while the Vmax remained to be constant, indicating a competitive inhibition of PAH upta
Publikováno v:
Chemical and Pharmaceutical Bulletin. 14:285-292
Various biological effects of androfurazanol, 17β-hydroxy-17α-methyl-5α-androstano[2, 3-c]furazan, were tested on rats and rabbits as compared wity those of stanozolol, 17β-hydroxy-17α-methyl-5α-androstano[3, 2-c]pyrazole. Androfurazanol was pr