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Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1172-1178
The sodium salt of isosteviol (STVNa) is a beyerane diterpene synthesized through acid hydrolysis of stevioside. STVNa improves multiple types of tissue injuries. However, it is not known how isosteviol sodium affects high-fat and high cholesterol di
Autor:
Hiroshi Watanabe, Kazuaki Taguchi, Toru Maruyama, Koji Nishi, Yasunori Iwao, Keishi Yamasaki, Masaki Otagiri, Yu Ishima, Sadaharu Matsushita
Publikováno v:
Biological & Pharmaceutical Bulletin. 40:1813-1817
Human serum albumin (HSA), the most abundant protein in serum, functions as carrier of drugs and contributes to maintaining serum colloid osmotic pressure. We report herein on the preparation of a genetic recombinant HSA, in which domains II and III
Autor:
Shinji Motomura, Shuichi Enomoto, Masashi Ueda, Hiroyuki Yasui, Masayuki Munekane, Shinichiro Kamino, Hiromitsu Haba, Yutaka Yoshikawa
Publikováno v:
Biological & Pharmaceutical Bulletin. 40:510-515
Many zinc (Zn) complexes have been developed as promising oral antidiabetic agents. In vitro assays using adipocytes have demonstrated that the coordination structures of Zn complexes affect the uptake of Zn into cells and have insulinomimetic activi
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 64:1555-1559
Activated carbon (AC) has been widely applied for adsorptive removal of organic contaminants from aqueous phase, but not for ionic pollutants. In this study, nitrogen doped AC was prepared to increase the adsorption capacity of nitrate from water. AC
Autor:
Ruizhuo Ouyang, Yang Yang, Shuang Zhou, Yaoqin Yang, Penghui Cao, Fei Xiong, Xiaoshen Zhang, Yuhao Li, Kai Feng, Yuqing Miao, Huihong Tao, Tianyu Zong, Ning Guo
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 64:1539-1545
6-Mercaptopurine (6-MP) is a clinically important antitumor drug and its commercially available form is provided as monohydrate, belonging to biopharmaceuticals classification system (BCS) class II category. The combination of bismuth(III) (Bi(III))
Publikováno v:
Biological & Pharmaceutical Bulletin. 39:138-142
Previous studies showed an increased prevalence of cataracts in postmenopausal women. In this study, we investigated changes in the levels of calcium ion (Ca(2+)) and interleukin (IL)-18, which are factors in cataract development, in the lenses of ov
Autor:
Takehiko Yasuji, Keiichi Yoshihara, Kazuhiro Sako, Yuuki Kasashima, Noriyuki Namiki, Shinya Uchida
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 64:1304-1309
The objective of this study was to establish the key factor of the lauryl sulfate (LS) salt/complex for sustained release of a hydrophilic drug at various physiological pH levels. Mirabegron is a hydrophilic drug that exhibits pH-dependent solubility
Autor:
Kimie Imai, Yui Tamezane, Minami Nakagawa, Kazuhiro Takahashi, Kunio Nakanishi, Ayano Iwazaki, Kenta Tanaka
Publikováno v:
Biological and Pharmaceutical Bulletin. 37:779-784
The interaction between angiotensin II type 1 (AT1) receptor blockers (ARBs), such as losartan potassium (LO), candesartan (CA), and telmisartan (TE), and dietary fiber was studied as to the level of free ARB in vitro. When ARB was incubated with sol
Autor:
Kousuke Akiyama, Hitoshi Yoshimitsu, Junei Kinjo, Toshihiro Nohara, Kazutaka Yamamoto, Masafumi Okawa, Masateru Ono, Tomoko Mineno
Publikováno v:
Chemical and Pharmaceutical Bulletin. 62:125-133
Three new acylated methyl glycosides and two new acylated glycosidic acid methyl esters were isolated after treatment of the crude ether-insoluble resin glycoside (convolvulin) fraction from seeds of Quamoclit pennata BOJER (Convolvulaceae) with indi
Autor:
Masafumi Okawa, Kazutaka Yamamoto, Toshihiro Nohara, Tomoko Mineno, Junei Kinjo, Hitoshi Yoshimitsu, Masateru Ono, Hiroyuki Miyashita, Kousuke Akiyama
Publikováno v:
Chemical and Pharmaceutical Bulletin. 62:830-835
Four new acylated glycosidic acid methyl esters were isolated after treatment of the crude ether-insoluble resin glycoside (convolvulin) fraction obtained from the seeds of Quamoclit pennata BOJER (Convolvulaceae) with indium(III) chloride in methano