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Publikováno v:
Biological and Pharmaceutical Bulletin. 28:1450-1454
This study was designed to investigate the effects of the aqueous ethanol extract of Astragalus membranaceus BUNGE (Leguminosae) on rat thoracic aorta. Isometric tension was recorded in response to drugs in organ bath. In endothelium-intact aortic ri
Autor:
Mark C. Walker, Ben S. Zweifel, Masao Sasamata, Aishi Kimoto, Masahiro Noguchi, Kazutoshi Nozaki, James K. Gierse
Publikováno v:
Biological and Pharmaceutical Bulletin. 28:2075-2079
We investigated the mechanism of inhibition of loxoprofen sodium, a non-steroidal anti-inflammatory drug (NSAID), and its active metabolite (loxoprofen-SRS) on cyclooxygenase (COX). In in vitro assays, loxoprofen sodium appeared inactive against reco
Autor:
Subhas S. Karki, Malaya Gupta, Upal Kanti Mazumder, S. Bhattacharya, Sivakumar Thangavel, Suresh Rathinasamy
Publikováno v:
Chemical and Pharmaceutical Bulletin. 52:178-185
In search of potential anticancer drug candidates in ruthenium complexes, a series of mononuclear ruthenium complexes of the type [Ru(phen)(2)(nmit)]Cl(2) (Ru1), [Ru(bpy)(2)(nmit)]Cl(2) (Ru2), [Ru(phen)(2)(icpl)]Cl(2) (Ru3), Ru(bpy)(2)(icpl)]Cl(2) (R
Publikováno v:
Biological and Pharmaceutical Bulletin. 26:295-298
An acid sialidase partially purified from porcine liver was activated by incubation at 37 degrees C under acidic pH. This activation was dependent on pH, time and temperature, but not inhibited by amastatin, an inhibitor of aminopeptidase A, in contr
Publikováno v:
Chemical and Pharmaceutical Bulletin. 51:625-629
3-Formyl-4-hydroxyphenylguanidine hydrochloride and its Schiff base copper(II), zinc(II), and iron(III) chelates were synthesized and their inhibitory activity against bovine beta-trypsin were determined. Syntheses of Schiff base metal chelates were
Autor:
Tomoko Nakamura, Takahiro Uchida, Kenji Matsuyama, Takeshi Akiyoshi, Atsu Tanigake, Tazuko Ogawa, Yohko Miyanaga
Publikováno v:
Chemical and Pharmaceutical Bulletin. 50:1589-1593
The purpose of this study was to quantify the degree of suppression of the perceived bitterness of quinine by various substances and to examine the mechanism of bitterness suppression. The following compounds were tested for their ability to suppress
Autor:
Tokiko Aikawa, Tadashi Ishii, Koki Shigenobu, Ryo-ichi Fujisaki, Yusuke Miyamoto, Yoshino Tanaka, Hikaru Tanaka, Toru Kawanishi, Wataru Hirayama
Publikováno v:
Biological and Pharmaceutical Bulletin. 25:323-326
Effects of Mn2+ on isolated guinea pig ventricular myocardia were examined. In isolated papillary muscles, Mn2+ produced a transient decrease in contractile force followed by a late sustained augmentation. Mn2+ markedly increased the amplitude of pos
Autor:
Shizuo Yamada, Akihiko Urayama, Kazufumi Hirano, Hiroshi Watanabe, Ryohei Kimura, Kyoichi Ohashi
Publikováno v:
Biological and Pharmaceutical Bulletin. 23:1189-1192
The effect of long-term administration of amlodipine and cilnidipine was examined on the histopathology and 1, 4-dihydropyridine (DHP) calcium channel antagonist receptors in the left ventricle of BIO TO-2 hamsters, a model of dilated cardiomyopathy
Publikováno v:
Biological and Pharmaceutical Bulletin. 23:487-491
SM-11355, cis[((1R, 2R)-1, 2-Cyclohexanediamine-N, N')bis(myristato)] platinum(II), is a lipophilic platinum complex.SM-11355 suspended in Lipiodol (SM-11355/Lipiodol) was shown to have antitumor activity against hepatic tumors after intra-hepatic ar
Publikováno v:
Biological and Pharmaceutical Bulletin. 23:1357-1362
The in vitro permeation of three diclofenac salts--diclofenac sodium (DFS), diclofenac potassium (DFP) and diclofenac diethylammonium (DFD)-across skin by both passive and iontophoretic transport were investigated. Various skin types were used as the