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Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1172-1178
The sodium salt of isosteviol (STVNa) is a beyerane diterpene synthesized through acid hydrolysis of stevioside. STVNa improves multiple types of tissue injuries. However, it is not known how isosteviol sodium affects high-fat and high cholesterol di
Autor:
Hiroshi Watanabe, Kazuaki Taguchi, Toru Maruyama, Koji Nishi, Yasunori Iwao, Keishi Yamasaki, Masaki Otagiri, Yu Ishima, Sadaharu Matsushita
Publikováno v:
Biological & Pharmaceutical Bulletin. 40:1813-1817
Human serum albumin (HSA), the most abundant protein in serum, functions as carrier of drugs and contributes to maintaining serum colloid osmotic pressure. We report herein on the preparation of a genetic recombinant HSA, in which domains II and III
Autor:
Shinji Motomura, Shuichi Enomoto, Masashi Ueda, Hiroyuki Yasui, Masayuki Munekane, Shinichiro Kamino, Hiromitsu Haba, Yutaka Yoshikawa
Publikováno v:
Biological & Pharmaceutical Bulletin. 40:510-515
Many zinc (Zn) complexes have been developed as promising oral antidiabetic agents. In vitro assays using adipocytes have demonstrated that the coordination structures of Zn complexes affect the uptake of Zn into cells and have insulinomimetic activi
Publikováno v:
Biological & Pharmaceutical Bulletin. 39:138-142
Previous studies showed an increased prevalence of cataracts in postmenopausal women. In this study, we investigated changes in the levels of calcium ion (Ca(2+)) and interleukin (IL)-18, which are factors in cataract development, in the lenses of ov
Autor:
Kimie Imai, Yui Tamezane, Minami Nakagawa, Kazuhiro Takahashi, Kunio Nakanishi, Ayano Iwazaki, Kenta Tanaka
Publikováno v:
Biological and Pharmaceutical Bulletin. 37:779-784
The interaction between angiotensin II type 1 (AT1) receptor blockers (ARBs), such as losartan potassium (LO), candesartan (CA), and telmisartan (TE), and dietary fiber was studied as to the level of free ARB in vitro. When ARB was incubated with sol
Publikováno v:
Biological and Pharmaceutical Bulletin. 33:1360-1363
Ligusticum wallichii is an herb widely used to treat vascular disorders in Asian countries, and tetramethylpyrazine (TMP) has been identified as one of its vasorelaxant active components. This study was performed to examine the endothelium-independen
Autor:
Shizuo Yamada, Luvsandorj Oyunzul, Shinya Uchida, Daiki Takahashi, Miyase Gözde Gündüz, Yoshihiko Ito, Chiat Safak, Satomi Onoue, Rahime Şimşek
Publikováno v:
Biological and Pharmaceutical Bulletin. 31:473-479
The present study was undertaken to investigate binding activity of synthesized 1,4-dihydropyridine (1,4-DHP) derivatives (Compounds 1--124) to 1,4-DHP calcium channel antagonist receptors in rat brain. Sixteen 1,4-DHP derivatives inhibited specific
Publikováno v:
Biological and Pharmaceutical Bulletin. 31:981-985
The ICR/f rat is a recessive-type hereditary cataractous strain, and opacity in the lens usually becomes evident at around 75 d of age. We previously found that the instillation of eye drops containing a disulfiram and hydroxypropyl-beta-cyclodextrin
Autor:
José Raúl Medina, Adriana Miriam Domínguez-Ramírez, Marcela Hurtado, Alba Jady Delgadillo, Alma Rosa Cortés, Kazuko Aoki
Publikováno v:
Biological and Pharmaceutical Bulletin. 29:1186-1190
The antispasmodic activity of extracts from the aerial parts of Buddleja scordioides and Buddleja perfoliata (family: Scrophulariaceae) was studied on isolated tissue preparations from rabbit and guinea pig intestine. The chloroformic extract from th
Autor:
Toyokichi Yoshizawa, Toshihiro Nohara, Xi Ying Zhao, Motoyuki Nakamura, Fumio Hashimoto, Wen Mei Yan, Yu Ming Chi, Shinobu Sakurada, Junei Kinjo
Publikováno v:
Biological and Pharmaceutical Bulletin. 29:489-493
The oral anti-inflammatory activity of 4,4'-dihydroxy-alpha-truxillic acid (1) was compared with that of two other nonsteroidal anti-inflammatory drugs, loxoprofen sodium (LOX) and diclofenac sodium (DIC). The activity of 1 against the inflammatory p