Zobrazeno 1 - 10
of 415
pro vyhledávání: ''
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1894-1897
The lusitropic effect of quercetin was examined on isolated ventricular myocardial tissue preparations from normal and streptozotocin-induced diabetic mice. The time required for 90% relaxation of the myocardium, which was prolonged in the diabetic m
Autor:
Tatsuya Kitao, Megumi Yamamoto, Masaki Fukui, Yuma Ito, Shohei Furukawa, Hiroaki Shirahase, Ko Morishita
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:659-668
Peroxisome proliferator-activated receptor γ (PPARγ) modulators are expected to exert anti-diabetic effects without PPARγ-related adverse effects, such as fluid retention, weight gain, and bone loss. The present study showed that the novel tetrazo
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1810-1813
An elevated plasma homocysteine level is an independent risk factor for cardiovascular diseases, neurological disorders, and pregnancy complications. We recently demonstrated partial lactation failure in cystathionine γ-lyase-deficient (Cth-/-) dam
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1172-1178
The sodium salt of isosteviol (STVNa) is a beyerane diterpene synthesized through acid hydrolysis of stevioside. STVNa improves multiple types of tissue injuries. However, it is not known how isosteviol sodium affects high-fat and high cholesterol di
Autor:
Nobuhiko Miura, Gi Wook Hwang, Sarah Tominaga, Tohru Maeda, Hiroki Yoshioka, Yasuro Shinohara
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:53-58
The aim of the present study was to investigate the "chronotoxicity" of streptomycin (SM) in relation to its circadian periodicity. Male ICR mice were injected intraperitoneally with SM (780 mg/kg, one shot) one of six time points throughout the day.
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:1726-1732
This study was conducted to investigate the effects of the extracts of green romaine lettuce (GRE) on sleep enhancement. GRE contains 1071.7 and 199.2 µg/g of extracts of lactucin and lactucopicrin, respectively, known as sleep enhancement substance
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:1575-1580
Cedrol has been reported to be effective in reducing anxiety of male mice. The limited application of females in animal models of anxiety makes it difficult to systematically investigate new drug substitutes with potential anxiolytic activity. In the
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:1423-1427
Age is known as one of influencing factor for theophylline (TP)-metabolizing capacity. In a previous our study, the ratio of TP and its major metabolite 1,3-dimethyluric acid (DMU) in serum (DMU/TP) is a useful index to estimate TP-metabolizing capac
Autor:
Shuo Yang, Jin-Ying Che, Xing-Xu Du, He Li, Jianguang Chen, Chunmei Wang, Shuang Liang, Xue Tao
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:1275-1281
Polysaccharide is a key bioactive component of Schisandra chinensis and has significant pharmacological activities. The aim of this study was to evaluate the anti-diabetic effect of acidic polysaccharide from Schisandra chinensis (SCAP). Type 2 diabe
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:1102-1111
This study aimed to evaluate the effects of combined use of tetrahydrobiopterin (BH4) and nebivolol on cardiac diastolic dysfunction in spontaneously hypertensive rats (SHRs). Twelve-week-old male SHRs were treated with BH4, nebivolol, or a combinati