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Autor:
Tatsuya Kitao, Megumi Yamamoto, Masaki Fukui, Yuma Ito, Shohei Furukawa, Hiroaki Shirahase, Ko Morishita
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:659-668
Peroxisome proliferator-activated receptor γ (PPARγ) modulators are expected to exert anti-diabetic effects without PPARγ-related adverse effects, such as fluid retention, weight gain, and bone loss. The present study showed that the novel tetrazo
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1172-1178
The sodium salt of isosteviol (STVNa) is a beyerane diterpene synthesized through acid hydrolysis of stevioside. STVNa improves multiple types of tissue injuries. However, it is not known how isosteviol sodium affects high-fat and high cholesterol di
Autor:
Arisa Kawahara, Kazuya Otake, Masaki Fukui, Hiroaki Shirahase, Satoru Azukizawa, Takeda Shigemitsu, Tatsuya Kitao
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 63:998-1014
A novel series of 2,7-substituted 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives were synthesized and biologically evaluated. (S)-2-(2-Furylacryloyl)-7-[2-(2-methylindane-2-yl)-5-methyloxazol-4-yl]methoxy-1,2,3,4-tetrahydroisoquinoline-
Autor:
Makoto Yamaguchi, Shoko Takai
Publikováno v:
Biological and Pharmaceutical Bulletin. 37:404-408
Inflammation has been implicated in development of the insulin resistance that leads to elevated blood sugar levels associated with type 2 diabetes. It is reported that salsalate, a common non-steroidal anti-inflammatory drug, has been shown to decre
Publikováno v:
Biological and Pharmaceutical Bulletin. 37:618-624
Uridine 5'-diphosphate (UDP)-glucuronosyltransferase 1A (UGT1A), which catalyzes major phase II reactions, is regulated by endogenous and exogenous factors via nuclear receptors such as the aryl hydrocarbon receptor (AhR). Glucocorticoid, one of the
Autor:
Yuko Yamaguchi, Midori Wakabayashi, Toshiaki Kogure, Yoshiharu Kobayashi, Daisuke Kiyonaga, Noriko Tagawa, Masafumi Ueda, Okiko Miyata
Publikováno v:
Biological and Pharmaceutical Bulletin. 35:1275-1280
Excess glucocorticoids promote visceral obesity and insulin resistance. The main regulator of intracellular glucocorticoid levels are 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts inactive glucocorticoid into bioactive glucocor
Publikováno v:
Biological and Pharmaceutical Bulletin. 35:1091-1095
The Goto-Kakizaki (GK) rat is a non-obese and spontaneous model of mild Type 2 diabetes mellitus. In the present study, we compared the regulatory mechanisms of endogenous norepinephrine (NE) release from sympathetic nerves of caudal arteries of 12-w
Publikováno v:
Biological and Pharmaceutical Bulletin. 34:1596-1601
The objective of the present study was to evaluate the cardiovascular protective effects of Danshensu, a water-soluble active component of Danshen, in spontaneously hypertensive rats (SHR). SHR (male, 9 weeks old, n=30) were divided into three groups
Publikováno v:
Biological and Pharmaceutical Bulletin. 34:980-986
We investigated the effects of the α(1)-adrenergic agonist phenylephrine on platelet-derived growth factor (PDGF)-stimulated extracellular signal-regulated kinase (ERK) in primary cultures of adult rat hepatocytes. Hepatocytes were isolated and cult
Publikováno v:
Biological and Pharmaceutical Bulletin. 34:1684-1689
Inhibition of Rho kinase (ROCK) ameliorates many cardiovascular dysfunctions. The aim of the current study is to investigate the anti-inflammatory effects of fasudil, a selective ROCK inhibitor, on high cholesterol diet-induced hypercholesterolemic r