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Autor:
Dong-Zong Hung, Jiunn-Wang Liao, Jaw Jou Kang, Yu Wen Cheng, Chien Ming Hu, Chi-Chung Chou, Yng Tay Chen
Publikováno v:
Journal of Health Science. 55:525-531
2-Chloroethanol (2-CE) is a commonly used solvent in industry; unfortunately, severe hypotension is one of main toxic signs during intoxication. Calcium ion modulation is considered to be an important role of vasorelaxation. The aim of this study is
Autor:
Yoshiyasu Higashikawa, Shinichi Suzuki
Publikováno v:
Journal of Health Science. 54:629-637
Although 1-(2-phenethyl)-4-(N-propionylanilino)piperidine (fentanyl) is controlled by drug control laws, its slightly modified compounds, which show the same analgesic activities, cannot be controlled legally. Among these fentanyl analogues, 1-[2-(2-
Autor:
Hiroyuki Inoue, Tatsuyuki Kanamori, Kenji Kuwayama, Tohru Kishi, Yuko T. Iwata, Kenji Tsujikawa, Hajime Miyaguchi
Publikováno v:
Journal of Health Science. 52:425-430
The in vivo metabolism of 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT), a psychoactive tryptamine analog, was studied in rat. Male Wistar rats were administered 10 mg/kg 5-MeO-DIPT hydrochloride orally, and urinary fractions were collected. After
Publikováno v:
Journal of Health Science. 51:257-262
Cetraxate hydrochloride (cetraxate), an antiulcer drug, produces a dose related increase in mucosal blood flow. We have reported that cetraxate increases plasma calcitonin gene-related peptide (CGRP) and substance P in healthy human subjects (J. Phar
Autor:
Xueqing Wang, Dong-Mei Li, Rui Juan Zhang, Qiang Zhang, Jian Cheng Wang, Wan-Liang Lu, Hua Zhang, Xuan Zhang, Gui Lin Wang
Publikováno v:
Journal of Health Science. 51:308-316
The objective of this study was to estimate the pharmacokinetics of the newly developed once-daily acemetacin sustained-release tablets compared with those of the commercial acemetacin sustained-release capsules. Ten male healthy Chinese volunteers w
Publikováno v:
Journal of Health Science. 50:389-395
There had been a smoking case in which dimethylamphetamine (DMA) and its metabolite DMA-N-oxide (DMAO) in addition to methamphetamine (MA) and amphetamine (AM), were detected in the abuser's urine. The analytical results of the confiscated leftover d
Publikováno v:
Journal of Health Science. 49:501-508
The deacylation of N-formylanilines and N-acetylanilines to aniline derivatives was examined in rat liver preparations. When N4-formylsulfanilamide or N4-acetylsulfanilamide was incubated with rat liver cytosol, the deacylated metabolite, sulfanilami
Publikováno v:
Eisei kagaku. 37:473-479
Enantiomeric compositions of methamphetamine (MA) and its major metabolite, amphetamine (AP), in the urine of mice administered with l-deprenyl (DPN), d-methamphetamine and dl-methamphetamine were analysed by the selected ion monitoring of gas chroma
Publikováno v:
Eisei kagaku. 32:276-280
A rapid and sensitive method for the simultaneous determination of nicotine and its principal metabolite, cotinine in the urine is described. An Extrelut column extraction procedure was introduced and the quantitative analyses were performed by gas c
Publikováno v:
Eisei kagaku. 22:280-285
After oral administration of noscapine (80-150 mg/kg) to male rabbits, detection of its urinary metabolites was carried out. The first 24-hr urine was extracted with CHCl3 at pH 8-9 (F-I) and the remaining urine was re-extracted with CHCl8 after acid