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Autor:
Tokiko Aikawa, Tadashi Ishii, Koki Shigenobu, Ryo-ichi Fujisaki, Yusuke Miyamoto, Yoshino Tanaka, Hikaru Tanaka, Toru Kawanishi, Wataru Hirayama
Publikováno v:
Biological and Pharmaceutical Bulletin. 25:323-326
Effects of Mn2+ on isolated guinea pig ventricular myocardia were examined. In isolated papillary muscles, Mn2+ produced a transient decrease in contractile force followed by a late sustained augmentation. Mn2+ markedly increased the amplitude of pos
Autor:
Shizuo Yamada, Akihiko Urayama, Kazufumi Hirano, Hiroshi Watanabe, Ryohei Kimura, Kyoichi Ohashi
Publikováno v:
Biological and Pharmaceutical Bulletin. 23:1189-1192
The effect of long-term administration of amlodipine and cilnidipine was examined on the histopathology and 1, 4-dihydropyridine (DHP) calcium channel antagonist receptors in the left ventricle of BIO TO-2 hamsters, a model of dilated cardiomyopathy
Autor:
Takashi KOBAYASHI, Teruhiko INOUE, Zyunichiro KITA, Haruo YOSHIYA, Shigeyoshi NISHINO, Kiyoshi OIZUMI, Tomio KIMURA
Publikováno v:
Chemical and Pharmaceutical Bulletin. 43:788-796
Novel 2-amino-1,4-dihydropyridine derivatives, which contain nitroxy-alkoxycarbonyl groups at the 3- and/or 5-position, were synthesized and their pharmaceutical effect was evaluated in spontaneously hypertensive rats. The structure-activity relation
Publikováno v:
Chemical and Pharmaceutical Bulletin. 50:741-743
Nifedipine-containing calcium phosphate cement (CPC) was prepared, and nifedipine (NF) release from this preparation was evaluated by the shaking method (SK), Japanese Pharmacopoeia XIV (JPXIV) paddle method (PD), and JPXIV flow-through cell method (
Autor:
Yoshiaki Okamiya, Hideo Kanno, Tatsuyuki Naruchi, Kiyotaka Sunakawa, Hisao Yamaguchi, Toru Takeshita
Publikováno v:
Chemical and Pharmaceutical Bulletin. 40:2049-2054
New 1, 4-dihydropyridine derivatives bearing a 4-(disubstituted phenyl) ring and an aminoethyl ester or an amino-2, 2-dimethylpropyl ester were synthesized and their antihypertensive activities were examined in normotensive rats and spontaneously hyp
Autor:
Yutaka Ohtaki, Chikara Fukaya, Atsuyuki Ashimori, Hideaki Kido, T. Uchida, Yoshiyuki Fujino, Yoshihisa Inoue, Masahiro Eda, Satoshi Morimoto, Masahiro Watanabe, Taizo Ono, Yasushi Ogura, Kazumasa Yokoyama
Publikováno v:
Chemical and Pharmaceutical Bulletin. 39:91-99
Novel 1, 4-dihydropyridine derivatives bearing 3-[4-(substituted amino)phenylalkyl]ester side chains were prepared and tested for their antihypertensive activity in spontaneously hypertensive rats. Most compounds showed a more potent antihypertensive
Autor:
Atsuyuki Ashimori, Yutaka Ohtaki, Taizo Ono, Chikara Fukaya, T. Uchida, Kazumasa Yokoyama, Masahiro Watanabe
Publikováno v:
Chemical and Pharmaceutical Bulletin. 38:2446-2458
A series of 4-(substituted pyridyl)-1,4-dihydropyridine derivatives were synthesized and their hypotensive effects examined. Several compounds, 2-(N-benzyl-N-methylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitro-2-pyridyl)-3,5-pyridinedicarbox
Autor:
Kenji Manno, Masao Koida, Masaki Ichikawa, Sawako Akashi, Miki Wanaka, Tomokazu Ohtsuji, Hiromichi Nakamuta, Yumiko Machidera
Publikováno v:
Biological and Pharmaceutical Bulletin. 17:1513-1515
Semotiadil fumarate, a novel benzothiazine calcium antagonist, was given alone or in combination with either enalapril or trichlormethiazide to conscious, spontaneously hypertensive, rats daily for 2 weeks. Systolic blood pressure and heart rate were
Autor:
Minoru Watanabe, Satoshi Narita
Publikováno v:
Journal of Pharmacobio-Dynamics. 5:285-294
Effects of calcium blockers and Mn on the mechanical response of the isolated rat iris sphincter and the dilator were investigated. The contraction of the sphincter in response to acetylcholine, the contraction of the dilator in response to norepinep