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Autor:
Tatsuya Takagi, Masao Nasu, Chizuko Hattori, Steffen Amann, Yuko Shirakuni, Tsugumichi Sato, Carla M. Van Bennekom
Publikováno v:
YAKUGAKU ZASSHI. 135:1161-1168
Thalidomide was approved for the treatment of multiple myeloma in Japan under a risk management program, named TERMS, in 2008. Since then, we have been conducting a survey of the stakeholders to assess the effectiveness of TERMS. These surveys showed
Publikováno v:
Journal of Health Science. 57:142-152
We researched the preventive and therapeutic activities of the extract of Ramulus Mori (ERM) to observe its effects on collagen-induced arthritis (CIA) in mice and to explore the mechanisms of ERM in the treatment of rheumatoid arthritis (RA). We exa
Autor:
Fahaid Al-Hashem, Moshira Rateb, Ibrahim M. Ibrahim, Mohammed A. Dallak, Esma R. Isenovic, Nermeen Bastawy, Ismaeel Bin-Jaliah, Sanja Soskic, Mohamed A Haidara
Publikováno v:
Journal of Health Science
The present study was designed to investigate the effect of insulin on insulin resistance (IR), plasma adiponectin level and expression of adiponectin receptors 1 (AdipoR1) in obese and streptozotocin-induced type 2 diabetic rats. Male Sprague-Dowley
Autor:
Mio Nakamoto, Gen-yuki Yamane, Tomohiro Yamauchi, Morio Tonogi, Hitoshi Ishigouoka, Takeshi Fukushima, Hideaki Ichiba, Yoichi Tanaka, Kazumichi Sato, Yoshio Inouye
Publikováno v:
Journal of Health Science. 56:684-689
TS-1 is an oral anticancer agent comprising three components: two biochemical modulators of 5-fluorouracil (5-FU) and tegafur (FT), a prodrug of 5-FU. TS-1 displays potent anti-tumor activity by maintaining effective 5-FU concentrations in serum for
Autor:
Fumihiko Kugawa, Akemichi Ueno
Publikováno v:
Journal of Health Science. 56:81-87
The multidrug treatment, CDF [cyclophosphamide (CPA), doxorubicin (DXR), and 5fluorouracil (5-FU)], is a common chemotherapy protocol for breast cancer. However, the molecular mechanisms underlying its toxicity for breast cancer cells remain unclear.
Publikováno v:
Journal of Health Science. 56:20-30
Diabetes enhances oxidative stress and exacerbates acute ischemic injury. Previous studies have demonstrated that infarct volumes were greater in diabetic animals caused by a transient cerebral ischemia as compared with non-diabetic animals. Ascorbic
Publikováno v:
Journal of Health Science. 55:215-225
Donepezil (acetyl cholinesterase inhibitor) is a mainstay of clinical intervention to contain memory deficits of Alzheimer’s disease. However, its beneficial role in endothelial dysfunction-associated dementia i.e. vascular dementia still needs to
Autor:
Shin Ichi Sugiura, Paul Sessink, Kiyofumi Yamada, Manabu Tanimura, Tomohiro Miyake, Hiroaki Nagata, Toshitaka Nabeshima, Youko Hamaguchi, Kyoko Tadokoro, Keiki Mori
Publikováno v:
Journal of Health Science. 55:750-756
Cancer treatment in Japan is considered to be very progressive in the use of antineoplastic agents. Pharmacists are required to compound more antineoplastic preparations recently and thus are at risk for exposure to antineoplastic agents. In Japan, h
Autor:
Toshihiko Ishida, Hiroaki Dobashi, Kentaro Susaki, Yoshiharu Takiguchi, Katuharu Kittaka, Hitoshi Kawazoe, Hitoshi Houchi, Noriyasu Fukuoka, Michiaki Tokuda, Tomohiro Kameda
Publikováno v:
Journal of Health Science. 55:435-440
We performed a prospective study to assess the optimal blood concentration of tacrolimus in Japanese patients with rheumatoid arthritis (RA). The dose of tacrolimus (1-3mg/day) was administered orally once daily after the evening meal, and the blood
Publikováno v:
Journal of Health Science. 55:910-922
Our previous studies demonstrated that topic application of recombinant human acid fibroblast growth factor (aFGF) significantly, but still not completely, improved in diabetic ulcer healing. To obtain a maximal therapy for diabetic ulcer healing, a