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Autor:
Yoichi Kumagai, Masakuni Degawa, Minako Okamoto, Masashi Sekimoto, Ryuzo Kurita, Misaki Kojima
Publikováno v:
Biological and Pharmaceutical Bulletin. 37:654-658
The strain and sex differences in serum total cholesterol (TC) levels were examined in F344 and Sprague-Dawley (SD) rats. A sex difference (male
Autor:
Yuichi Kakoi, Yoshihisa Nakada, Masaki Ogino, Takeo Wada, Kazuki Kubo, Ryosuke Tokunoh, Hiromitsu Fuse, Shigekazu Itokawa, Seiji Fukui, Satoshi Nishimura, Shogo Marui, Tsukasa Sanada
Publikováno v:
Chemical and Pharmaceutical Bulletin. 59:1268-1273
Acyl-CoA: cholesterol acyltransferase (ACAT) is an intracellular enzyme that catalyzes cholesterol esterification. ACAT inhibitors are expected to be potent therapeutic agents for the treatment of atherosclerosis. A series of potent ACAT inhibitors b
Autor:
Yoshimichi Shoji, Masayasu Kasai, Tomohiro Miike, Chisato Mukai, Masaru Ohta, Kazuyoshi Kunishiro, Kenji Takahashi, Hiroaki Shirahase, Mamoru Kanda
Publikováno v:
Chemical and Pharmaceutical Bulletin. 58:1066-1076
To find a novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor with anti-lipid peroxidative activity, a series of tetrahydroisoquinoline derivatives were synthesized and evaluated. A compound with a N-(4-hydroxy-2,3,5-trimethylphenyl)carbamoy
Autor:
Shigeru Miyazaki, Yasuo Shiota, Fumie Hashimoto, Shojiro Kano, Kengo Kiyota, Teruhiko Matsushima, Katsuyoshi Uchino, Teruaki Kobayashi, Hidenori Hayashi, Mitsunobu Kawamura
Publikováno v:
Biological and Pharmaceutical Bulletin. 31:340-347
We examined the correlations between serum dolichol levels and laboratory test parameters in patients affected by disease, as well as the distribution of dolichol in sera from patients with hyperbetalipoproteinemia and hyperalphalipoproteinemia. Seru
Autor:
Chuthamanee Suthisisang, Anocha Utaipat, Vilasinee Hirunpanich, Nuntavan Bunyapraphatsara, Angkana Herunsalee, Noppawan Phumala Morales, Hitoshi Sato
Publikováno v:
Biological and Pharmaceutical Bulletin. 28:481-484
The present study quantitatively investigated the antioxidant effects of the aqueous extracts from dried calyx of Hibiscus sabdariffa LINN. (roselle) in vitro using rat low-density lipoprotein (LDL). Formations of the conjugated dienes and thiobarbit
Publikováno v:
Biological and Pharmaceutical Bulletin. 26:687-690
A chitosan (CS)-orotic acid salt (CS-OT) was prepared, and the release of orotic acid (OT) from CS-OT as well as the adsorption of bile acids by CS-OT was investigated in vitro. The amount of OT released from CS-OT was about 2-2.7 micromol/mg CS-OT a
Autor:
Akihisa Yoshimi, Yoshihiko Tauchi, Juichi Sato, Kazuhiro Morimoto, Hiroaki Shirahase, Keiji Ito
Publikováno v:
Biological and Pharmaceutical Bulletin. 26:73-78
KV-2920 is a novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor. To confirm the efficacy of KV-2920-low density lipoprotein (LDL) complex (KV-LDL complex) as a drug-carrier complex on experimental atherosclerosis, we examined its inhibitory
Publikováno v:
Biological and Pharmaceutical Bulletin. 26:854-857
The pancreatic lipase inhibitory activity of the rhizome of Alpinia officinarum (AO) and its antihyperlipidemic activity were measured. When the water extract of AO was fractionated stepwise with organic solvents, the ethyl acetate fraction exhibited
Autor:
Kenji Ohishi, Teruo Yokokura, Ritsuo Aiyama, Yasue Wada, Tsunekazu Watanabe, Yasuto Yoshida, Wakae Yokoi, Haruji Sawada, Hiroshi Hatano
Publikováno v:
Chemical and Pharmaceutical Bulletin. 49:830-839
A novel series of acyl-CoA: cholesterol O-acyltransferase (ACAT) inhibitors were synthesized from a lead compound, 1-(4-hydroxy-3-methoxyphenyl)-7-phenylhept-1-en-3-one (1, Yakuchinone B) through a modification of three regions (A, B, C) in the molec
Publikováno v:
Biological and Pharmaceutical Bulletin. 20:315-321
The effect of gemfibrozil, and analogue of clofibric acid, on the centrifugal behavior of peroxisomes and activity of peroxisomal enzymes involved in lipid metabolism was studied. Rats were fed chow containing 0.2% gemfibrozil for 2 weeks. Nycodenz g