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Autor:
Kazuhiko Shibata, Takahiro Niimura, Mami Uchida, Noriaki Hidaka, Yoshihisa Kitamura, Kenshi Takechi, Keisuke Ishizawa, Hiroyuki Namba, Mamoru Tanaka, Hitoshi Kawazoe, Hiromu Kawasaki, Soichiro Ushio, Toshiaki Sendou, Yoshito Zamami, Akihiro Tanaka, Shingo Takatori, Hiroaki Araki
Publikováno v:
Biological and Pharmaceutical Bulletin. 45:226-234
Oxaliplatin (OXA) is used in chemotherapy for various cancer types and is associated with acute and chronic neurotoxicity. However, a preventive strategy for OXA-induced peripheral neuropathy (OIPN) and its underlying mechanism remain unclear. We exa
Autor:
Junzo Kamei
Publikováno v:
YAKUGAKU ZASSHI. 141:1333-1342
An increasing number of patients complain to medical institutions about a cough that persists for more than 8 weeks, namely chronic cough. The cough observed in patients with chronic cough is not responsive to conventional antitussive agents such as
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1894-1897
The lusitropic effect of quercetin was examined on isolated ventricular myocardial tissue preparations from normal and streptozotocin-induced diabetic mice. The time required for 90% relaxation of the myocardium, which was prolonged in the diabetic m
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1585-1592
Tyrosine kinase 2 (Tyk2) is a member of the Janus family of protein tyrosine kinases (Jaks). Tyk2 associates with interferon (IFN)-α, IFN-β, interleukin (IL)-6, IL-10, IL-12, and IL-23 receptors and mediates their downstream signaling pathways. Bas
Autor:
Tsutomu Suzuki, Hirokazu Mishima, Mika Kobayashi, Masahide Fujita, Yasuhide Morioka, Motoji Kitaura, Katsumi Koike, Kana Yasufuku, Shino Takenouchi, Hiroki Chiba, Minoru Hasegawa
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1746-1751
Tramadol is a weak opioid that produces analgesic effect via both the μ-opioid receptor (MOR) and non-opioid targets. Constipation is the most common opioid-related side effect in patients with cancer and non-cancer pain. However, the contribution o
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1303-1308
Peroxisome proliferator-activated receptor gamma (PPARγ) is a master transcription factor in adipocyte differentiation, while distal-less homeobox 5 (Dlx5) is essential for initiating osteoblast differentiation by driving Runt-related transcription
Autor:
Yume Hattori, Yohei Ikegami, Yukako Abe, Naoya Iwata, Yoshio Tanaka, Nanako Shioda, Yuka Matsuoka, Kazuhiro Matsuo, Kento Yoshioka, Keisuke Obara, Shoko Hamamatsu, Takashi Yoshio, Fumiko Yamaki
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1140-1150
The clinical applications of antipsychotics for symptoms unrelated to schizophrenia, such as behavioral and psychological symptoms, in patients with Alzheimer's disease, and the likelihood of doctors prescribing antipsychotics for elderly people are
Autor:
Iqbal Julian, Takuya Iwamoto
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1050-1059
Skin rash is a common adverse event associated with erlotinib therapy. In severe conditions, the rash could affect patients' QOL. If the rash occurrence can be predicted, erlotinib treatment failures can be prevented. We designed an in vivo study tha
Autor:
Kazuya Ooi
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1037-1043
Dry skin is a common symptom of various conditions, and elderly individuals commonly exhibit this physiological symptom. Dry skin develops owing to sebum deficiency; however, the use of moisturizers can typically overcome this issue, particularly in
Autor:
Masayo Komoda
Publikováno v:
YAKUGAKU ZASSHI. 141:887-909
The difficult experience of treating scabies in an elderly hospital reaffirmed my determination and responsibilities as a pharmacist. In 2000, there was no effective treatment for scabies in Japan. With the Japan Pharmaceutical Association as well as