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Autor:
Yoshihiro Natori
Publikováno v:
YAKUGAKU ZASSHI. 141:15-24
Iminosugars are one of the compounds that mimic the structure of monosaccharides. Such sugar mimics have the ability to effectively and specifically inhibit various glycosidases and glycosyltransferases. After studying iminopyranose, miglitol, which
Autor:
Chiaki Kamei
Publikováno v:
YAKUGAKU ZASSHI. 141:93-110
There has been little information about the role of histamine on the central nervous system (CNS), different from dopamine and serotonin. In the present study, therefore, the effects of histamine and related compounds on the CNS were studied using ra
Autor:
Yoshitaka Saito
Publikováno v:
YAKUGAKU ZASSHI. 140:1415-1419
Management of chemotherapy-induced adverse effects and the associated pharmaceutical interventions as well as supportive care evidence creation are the most important responsibilities of oncology pharmacists. We have evaluated the (1) efficacy of lon
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1876-1883
Ionizing radiation induces severe oxidative stress, resulting in individual death by acute radiation syndrome. The nuclear factor-erythroid-2-related factor 2 (Nrf2) plays an important role in the antioxidant response pathway. Recently, romiplostim (
Autor:
Masahiro Ono, Hideo Saji, Yoichi Shimizu, Hiroyuki Watanabe, Ning Ding, Takeshi Namita, Kohei Sano, Tsuyoshi Shiina
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1859-1866
Surgery remains one of the main treatments of cancer and both precise pre- and intraoperative diagnoses are crucial in order to guide the operation. We consider that using an identical probe for both pre- and intra-operative diagnoses would bridge th
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1810-1813
An elevated plasma homocysteine level is an independent risk factor for cardiovascular diseases, neurological disorders, and pregnancy complications. We recently demonstrated partial lactation failure in cystathionine γ-lyase-deficient (Cth-/-) dam
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1556-1561
Renal insufficiency secondary to contrast administration remains a prevalent and debilitating complication of angiographic procedures. Contrast-induced nephropathy (CIN) is a common clinical problem for which there is no effective medical treatment.
Autor:
Hideaki Nakamura
Publikováno v:
YAKUGAKU ZASSHI. 140:1243-1249
Here the author describes the tumor-selective delivery of a fluorescence photosensitizing agent and an antitumor agent, based on the polymer effect of an N-(2-hydroxypropyl)methacrylamide (HPMA) based copolymer, by utilizing the enhanced permeability
Autor:
Mai Hashimoto, Shuhei Imoto, Kazuaki Taguchi, Hiroaki Mitsuya, Keishi Yamasaki, Masaki Otagiri
Publikováno v:
Biol Pharm Bull
A nucleoside analog, 4′-cyano-2′-deoxyguanosine (CdG), which was developed as an inhibitor of the chronic hepatitis B virus (HBV), exhibited a superior antiviral activity against both wild-type and drugs-resistant HBV to marketed nucleoside analo
Autor:
Tsumugi Eifuku, Noriaki Nagai, Tomonori Hayashi, Hinako Kawaguchi, Atsufumi Kawabata, Hiroshi Matsuoka
Publikováno v:
Chemical and Pharmaceutical Bulletin. 68:879-884
The percutaneous absorption of a fentanyl (FEN)-patch is affected by various external factors including the volume of sebum secretion, which causes changes in the skin surface environment. In this study, we prepared a lard-based sebum-like secretion