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Autor:
Junichi Kurihara, Naho Maruyama, Kentaro Ninomiya, Sanae A. Ishijima, Shigeru Abe, Hiroshi Irie, Kazumi Hayama
Publikováno v:
Biological and Pharmaceutical Bulletin. 36:838-844
The onset of oral candidiasis is accompanied by inflammatory symptoms such as pain in the tongue, edema or tissue damage and lowers the quality of life (QOL) of the patient. In a murine oral candidiasis model, the effects were studied of terpinen-4-o
Autor:
Hyun-Woo Kim, Jae-Gyun Choi, Yong Sup Shin, Jae-Min Kim, Youngkwon Ko, Jin Bong Park, Hyung Sun Lim, Beyong Hwa Jeon, Jang Hern Lee
Publikováno v:
Biological and Pharmaceutical Bulletin. 36:125-130
Peripheral or central nerve injury often leads to neuropathic pain. Although ketamine and pregabalin are first line options for the treatment of neuropathic pain, their clinical application is limited due to side effects such as sedation, dizziness a
Autor:
Yoshio Kusakabe, Masayuki Nakanishi, Tomonobu Umeda, Yukio Kitade, Nobutada Tanaka, Kazuo T. Nakamura
Publikováno v:
YAKUGAKU ZASSHI. 133:527-537
The human malaria parasite Plasmodium falciparum is responsible for the death of more than a million people each year. The emergence of strains of this malaria parasite resistant to conventional drug therapy has stimulated the search for antimalarial
Autor:
Baoxiang Zhuang, Lin Wang, Daijuan Zhang, Jianying Wang, Tongmei Liu, Jiangyue Liu, Jianping Hou, Wentao Li
Publikováno v:
Biological and Pharmaceutical Bulletin. 36:733-740
3,4-Dihydroxyacetophenone (3,4-DHAP) is one herbal extract from bald Mao-dong-qing leaves. We reported that 3,4-DHAP had anti-inflammatory function by decreasing tumor necrosis factor-α (TNF-α) secretion in macrophages. The aim of the study was to
Autor:
Jianchun Pan, Mengchun Chen, Xianqin Wang, Jianshe Ma, Xiaole Chen, Guo-Xin Hu, Lufeng Hu, Guanyang Lin
Publikováno v:
Biological and Pharmaceutical Bulletin. 36:1627-1633
Hydrogen sulfide (H₂S) is one of the neurotoxic gases with suffocating and irritating. Its main target organs of toxic effects are the central nervous system and respiratory system. Cocktail method was used to evaluate the influence of chronic hydr
Publikováno v:
Biological and Pharmaceutical Bulletin. 36:1921-1927
Triple-negative breast cancer (TNBC) has a poor prognosis compared to other subtypes, and effective treatment options are limited to cytotoxic agents, including microtubule-targeting agents, due to the lack of molecular targets. Here, we examined the
Publikováno v:
Biological and Pharmaceutical Bulletin. 36:1396-1400
The serotonergic nervous system plays crucial roles in regulating psycho-emotional, cognitive, sensori-motor and autonomic functions. It is now known that multiple serotonin (5-hydroxytryptamine; 5-HT) receptors regulate extrapyramidal motor function
Autor:
Nobuko Minagawa
Publikováno v:
YAKUGAKU ZASSHI. 132:1093-1098
Living organisms have developed a wide variety of energy metabolism to survive within the specialized environments. There is a remarkable diversity in mitochondrial electron transport system, which might be potential targets for chemotherapy. Atovaqu
Autor:
Yasuhiro Suzuki
Publikováno v:
YAKUGAKU ZASSHI. 132:1019-1024
To investigate cerebral infarction and intracranial hemorrhage (ICH) in relation to antithrombotic agents, we established an animal stroke model induced by using a combination of a photosensitive dye and local green photoillumination. Microplasmin (
Autor:
Yuki Takahashi
Publikováno v:
YAKUGAKU ZASSHI. 132:1057-1061
Interferon-γ (IFN-γ) is a type II IFN that possesses various biological activities including antivirus effect and antitumor effect. Because of its potent biological activities, IFN-γ has been used as a therapeutic treatment for cancer patients and