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Publikováno v:
Biological and Pharmaceutical Bulletin. 35:2192-2197
Grape seed proanthocyanidin extracts (GSPE) belonging to polyphenols, possess various biological effects including anti-inflammation, anti-oxidant, anti-aging, anti-atherosclerosis, etc. GSPE is potential in regulating endothelial function. However,
Publikováno v:
Biological and Pharmaceutical Bulletin. 35:1091-1095
The Goto-Kakizaki (GK) rat is a non-obese and spontaneous model of mild Type 2 diabetes mellitus. In the present study, we compared the regulatory mechanisms of endogenous norepinephrine (NE) release from sympathetic nerves of caudal arteries of 12-w
Autor:
Toru Imohata, Megumi Furukawa, Naoki Oikawa, Takashi Iida, Yasuo Fujimoto, Mitsuko Makino, Susumu Kitanaka, Shoujiro Ogawa
Publikováno v:
Chemical and Pharmaceutical Bulletin. 60:397-401
Three new monoterpene glucosides, ziziphoroside A (1), B (2), and C (3), together with fifteen known compounds were isolated from the whole herb of Z. clinopodioides. The structures of new compounds were determined primarily from 1D-, 2D-NMR and circ
Autor:
Ryoji Nishimura, Naoki Uchida, Kotaro Takasaki, Kanako Uchida, Shutaro Katsurabayashi, Keiichi Irie, Kaori Kubota, Katsunori Iwasaki, Kenichi Mishima, Michihiro Fujiwara, Taro Shindo, Rika Onimura
Publikováno v:
Biological and Pharmaceutical Bulletin. 35:2141-2147
Telmisartan, an angiotensin type 1 receptor blocker, is used in the management of hypertension to control blood pressure. In addition, telmisartan has a partial agonistic effect on peroxisome proliferator activated receptor γ (PPARγ). Recently, the
Publikováno v:
Biological and Pharmaceutical Bulletin. 35:698-704
An ultra high-sensitivity method for quantifying fexofenadine concentration in rat plasma samples by multiple injection method (MIM) was developed for a microdose study. In this study, MIM involved continuous injections of multiple samples containing
Publikováno v:
Chemical and Pharmaceutical Bulletin. 60:976-984
The aim of the present study was to mask the bitterness of propiverine hydrochloride (P-4) by converting it to propiverine free base. Fine granules comprising the free base, which was converted from P-4 by desalination, were prepared. By using Fourie
Publikováno v:
Biological and Pharmaceutical Bulletin. 35:1-9
We investigated the properties of honokiol, a natural rexinoid, as a regulator of retinoid X receptor (RXR) heterodimers with various partner nuclear receptors (NRs), in comparison with those of the synthetic rexinoid bexarotene. Honokiol alone was h
Autor:
Yu-Ran Na, Ho-Youl Lee, Hyunju Cho, Keun Byeol Lee, Myong Jin Lee, Hyunsung Park, Cheolju Lee, Eun Gyeong Yang, So Yeon Kim, Jeong Won Kim, You Mie Lee
Publikováno v:
Biological and Pharmaceutical Bulletin. 35:2160-2169
We previously found that clioquinol (CQ) increases functional hypoxia-inducible factor-1α (HIF-1α) with enhanced transcription of its target genes. Here we report that compounds derived from 8-hydroxyquinoline including CQ, broxyquinoline (BQ), iod
Publikováno v:
YAKUGAKU ZASSHI. 131:1667-1674
We previously reported that oral administration of NK-4, a criptocyanine dye, enhances interleukin (IL)-12-depend- ent interferon (IFN)-γ production by lipopolysaccharide (LPS)-stimulated mouse splenocytes. These findings raised a possibility that N
Autor:
Izuru Kakuta, Kiyomi Takase
Publikováno v:
YAKUGAKU ZASSHI. 131:1473-1481
The present study was carried out to examine the chemopreventive effects of 5-fluorouracil (5-FU) and lactoferrin (LF) on goldfish intestinal carcinogenesis induced by 1,2-dimethylhydrazine (DMH). DMH was given to fish by intraperitoneal injection in