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Autor:
Kazuhiko Shibata, Takahiro Niimura, Mami Uchida, Noriaki Hidaka, Yoshihisa Kitamura, Kenshi Takechi, Keisuke Ishizawa, Hiroyuki Namba, Mamoru Tanaka, Hitoshi Kawazoe, Hiromu Kawasaki, Soichiro Ushio, Toshiaki Sendou, Yoshito Zamami, Akihiro Tanaka, Shingo Takatori, Hiroaki Araki
Publikováno v:
Biological and Pharmaceutical Bulletin. 45:226-234
Oxaliplatin (OXA) is used in chemotherapy for various cancer types and is associated with acute and chronic neurotoxicity. However, a preventive strategy for OXA-induced peripheral neuropathy (OIPN) and its underlying mechanism remain unclear. We exa
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1894-1897
The lusitropic effect of quercetin was examined on isolated ventricular myocardial tissue preparations from normal and streptozotocin-induced diabetic mice. The time required for 90% relaxation of the myocardium, which was prolonged in the diabetic m
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1303-1308
Peroxisome proliferator-activated receptor gamma (PPARγ) is a master transcription factor in adipocyte differentiation, while distal-less homeobox 5 (Dlx5) is essential for initiating osteoblast differentiation by driving Runt-related transcription
Autor:
Yume Hattori, Yohei Ikegami, Yukako Abe, Naoya Iwata, Yoshio Tanaka, Nanako Shioda, Yuka Matsuoka, Kazuhiro Matsuo, Kento Yoshioka, Keisuke Obara, Shoko Hamamatsu, Takashi Yoshio, Fumiko Yamaki
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1140-1150
The clinical applications of antipsychotics for symptoms unrelated to schizophrenia, such as behavioral and psychological symptoms, in patients with Alzheimer's disease, and the likelihood of doctors prescribing antipsychotics for elderly people are
Autor:
Yuki Takada-Takatori
Publikováno v:
YAKUGAKU ZASSHI. 141:851-856
Donepezil, the most widely used drug for the treatment of Alzheimer's disease (AD), is an acetylcholinesterase (AChE) inhibitor and is thought to improve cognition by stimulating cholinergic neurotransmission. However, no correlation has yet been est
Autor:
Napason Chabang, Somsak Fongsupa, Sirima Soodvilai, Sunhapas Soodvilai, Penjai Thongnuanjan, Pornpun Vivithanaporn, Patoomratana Tuchinda
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:830-837
Background Cisplatin is an effective chemotherapy but its main side effect, acute kidney injury, limits its use. Panduratin A, a bioactive compound extracted from Boesenbergia rotunda, shows several biological activities such as anti-oxidative effect
Autor:
Tatsuya Kitao, Megumi Yamamoto, Masaki Fukui, Yuma Ito, Shohei Furukawa, Hiroaki Shirahase, Ko Morishita
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:659-668
Peroxisome proliferator-activated receptor γ (PPARγ) modulators are expected to exert anti-diabetic effects without PPARγ-related adverse effects, such as fluid retention, weight gain, and bone loss. The present study showed that the novel tetrazo
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:550-556
We previously reported a screening method for caloric restriction mimetics (CRM), a group of plant-derived compounds capable of inducing good health and longevity. In the present study, we explored the possibility of using this method to screen CRM d
Publikováno v:
YAKUGAKU ZASSHI. 141:427-431
Daptomycin (DAP) has a completely different mechanism of action compared with conventional drugs for methicillin-resistant Staphylococcus aureus (MRSA) and is widely used as the first-line drug for treatment of dermal soft tissue infection and sepsis
Autor:
Hiroko Nakamura, Takehiro Kawashiri, Daisuke Kobayashi, Takao Shimazoe, Nobuaki Egashira, Mayako Uchida
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:271-274
The anticancer agents including oxaliplatin, paclitaxel, and bortezomib cause severe peripheral neuropathy. The Kampo medicine Sokeikakketsuto (SOKT) has been widely used to treat several types of pain. In this study, the analgesic effects of SOKT on