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Publikováno v:
Chemical and Pharmaceutical Bulletin. 66:327-333
Palmitoyl-glycine-histidine (Pal-GH) is a new low molecular weight gelling agent. It exhibits thixotropic behavior, low viscosity, and high dissolving properties for a wide range of hydrophilic to lipophilic drugs. Orally administered ivermectin (IVM
Publikováno v:
Biological & Pharmaceutical Bulletin. 40:992-1001
The pharmacological profile of fimasartan, [2-n-butyl-5-dimethylamino-thiocarbonyl-methyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}-pyrimidin-4(3H)-one, a new non-peptide angiotensin type 1 (AT1)-selective angiotensin receptor antagonis
Autor:
Takashi Hirota, Anri Fujishiro, Hideaki Ohashi, Yuka Matsuoka, Ayumi Hiramatsu, Atsushi Miyajima
Publikováno v:
Biological & Pharmaceutical Bulletin. 39:927-934
During the past two decades, it has been reported that treatment with all-trans-retinoic acid (ATRA) induces alveolar regeneration in rodent emphysema models. In the present study, we investigated the regeneration by ATRA at various exposure conditio
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 64:1546-1554
Quetiapine (QTP) is an atypical antipsychotic drug commonly used to treat several psychiatric disorders and is metabolized into the active metabolite norquetiapine (NQTP). This study was designed to evaluate and compare the physicochemical properties
Autor:
Isamu Murata, Ikuo Kanamoto, Masayuki Kimura, Yutaka Inoue, Narutoshi Arai, Aishi Fukushima, Astuko Saito
Publikováno v:
YAKUGAKU ZASSHI. 135:1049-1055
Cancer patients often report a decreased quality of life due to cancer-related pain, especially neuropathic pain, which is difficult to manage and often develops resistance to morphine. Thus a supplementary analgesic can play an important role in the
Autor:
Noritaka Nakamichi, Takuya Shimizu, Yusuke Masuo, Ai Kijima, Saki Takahashi, Tomoko Sugiura, Takahiro Ishimoto, Yukio Kato
Publikováno v:
Biological & Pharmaceutical Bulletin. 38:774-780
5-Aminosalicylic acid (5-ASA) is an orally administered therapeutic agent for inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease. We hypothesized that the absorption of 5-ASA is mediated by the polyspecific carnitine/organic
Autor:
Nadezhda Fefelova, Minfeng Fang, Lai-Hua Xie, Zhenghang Zhao, Dandan Xiao, Wei-Jin Zang, Chen Huang, Mei Liu
Publikováno v:
Biological & Pharmaceutical Bulletin. 36:238-244
3,4,5-Trimethoxycinnamic acid (TMCA), methyl 3,4,5-trimethoxycinnamate (M-TMCA) and p-methoxycinnamic acid (PMCA) have been identified as the major bioactive components in the serum collected from rats treated with oral administration of Polygalae Ra
Dynamic Analysis of Pharmacokinetics of Orally Administered Drugs Using Positron Emission Tomography
Autor:
Makoto Kataoka
Publikováno v:
YAKUGAKU ZASSHI. 132:911-917
Positron emission tomography (PET) is a powerful and noninvasive technology for molecular imaging in living systems. Its high sensitivity and high spatial-temporal resolution make this technology particularly useful to analyze the disposition of drug
Publikováno v:
Biological and Pharmaceutical Bulletin. 35:2230-2237
Non-steroidal anti-inflammatory drugs (NSAIDs) comprise one of the most frequently used classes of medicines in the world; however, NSAIDs have significant side effects, such as gastroenteropathy, and rheumatoid arthritis patients taking NSAIDs are m
Autor:
Izuru Kakuta, Kiyomi Takase
Publikováno v:
YAKUGAKU ZASSHI. 131:1473-1481
The present study was carried out to examine the chemopreventive effects of 5-fluorouracil (5-FU) and lactoferrin (LF) on goldfish intestinal carcinogenesis induced by 1,2-dimethylhydrazine (DMH). DMH was given to fish by intraperitoneal injection in