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Stereoselective Recognition of Amethopterin Enantiomers by the Rat Proton-Coupled Folate Transporter
Publikováno v:
Biological & Pharmaceutical Bulletin. 38:545-551
The stereoselective transport of methotrexate (L-amethopterin, L-MTX) and its enantiomer (D-amethopterin, D-MTX) by the rat proton-coupled folate transporter (rPCFT) were examined using rPCFT-expressing HEK293 cells. The initial rate of uptake of [3H
Autor:
P. S. Rajinikanth, Brahmeshwar Mishra
Publikováno v:
Chemical and Pharmaceutical Bulletin. 57:1068-1075
Gellan gum based floating beads containing clarithromycin (FBC) were prepared by iontotropic gelation method for stomach-specific drug delivery against Helicobacter pylori. The scanning electron microscope photograph indicated that prepared beads wer
Autor:
Shintaro Fumoto, Mikiro Nakashima, Junya Nishi, Yukinobu Kodama, Koyo Nishida, Junzo Nakamura, Hitoshi Sasaki
Publikováno v:
Biological and Pharmaceutical Bulletin. 31:1049-1052
The present study was undertaken to elucidate the absorption and distribution characteristics of 5-fluorouracil (5-FU) after its application to the liver surface in rats to examine the possibility of reducing the systemic side effects of this agent.
Autor:
Noboru Yamaguchi, Masahiro Otomo, Kenichi Osada, Hiroshi Miyoshi, Hideki Nakashima, Kiyofumi Takahashi
Publikováno v:
Biological and Pharmaceutical Bulletin. 31:1489-1495
Neuronal dynamin I plays a critical role in the recycling of synaptic vesicles, and thus in nervous system function. We expressed and purified dynamin I to explore potentially clinically useful endocytosis inhibitors and to examine the mechanism of t
Publikováno v:
Biological and Pharmaceutical Bulletin. 30:1648-1652
Three isoforms of anionic chum salmon trypsin (ST-1, ST-2, and ST-3) were purified from the pyloric caeca of chum salmon (Oncorhynchus keta). The molecular weights of the three isoforms were about 24 kDa as determined by SDS-PAGE. The isoelectric poi
PEGylated Liposomes Loading Palmitoyl Prednisolone for Prolonged Blood Concentration of Prednisolone
Autor:
Koyo Nishida, Shigeru Kawakami, Mugen Teshima, Hiroo Nakagawa, Junzo Nakamura, Mikiro Nakashima, Nobuhiro Ichikawa, Shintaro Fumoto, Hitoshi Sasaki
Publikováno v:
Biological & Pharmaceutical Bulletin. 29(7):1436-1440
We investigated the pharmacokinetic behavior of palmitoyl prednisolone (Pal-PLS) and its liposomes with L-α-distearoylphosphatidylcholine (DSPC) and cholesterol (Chol) with or without L-α-distearoylphosphatidylethanolamine-polyethylene glycol 2000
Autor:
Satoshi Endo, Kengo Matsumoto, Shuhei Ishikura, Ossama El-Kabbani, Toshiyuki Matsunaga, Kazuo Tajima, Akira Hara
Publikováno v:
Biological and Pharmaceutical Bulletin. 29:539-542
AKR1C20, a member of the aldo-keto reductase (AKR) superfamily, found by mouse genomic analysis, exhibits the highest sequence identity (89%) with mouse liver 17beta-hydroxysteroid dehydrogenase (HSD) type 5, but its function remains unknown. In this
Autor:
Shizuo Narimatsu, Tetsuo Satoh, Yoshihiko Funae, Hiroyuki Hichiya, Takashi Isobe, Sumio Shinoda, Shigeo Yamamoto, Nobumitsu Hanioka, Shigeru Yamano
Publikováno v:
Biological and Pharmaceutical Bulletin. 28:634-640
Inhibitory effects of desipramine (DMI) on rat and human CYP2D enzymes were studied using bufuralol (BF) 1''-hydroxylation as an index. Inhibition was examined under the following two conditions: 1) DMI was co-incubated with BF and NADPH in the react
Autor:
Yuko Okada, Ryuya Horiuchi, Koujirou Yamamoto, Shin Hosokawa, Katsunori Nakamura, Jing Wei Qi
Publikováno v:
Biological and Pharmaceutical Bulletin. 28:1467-1471
Time-dependent effects of St. John's wort (SJW) on midazolam 1-hydroxylation were investigated in Wistar rats. Wistar rats treated with SJW (1000 mg/kg/d) for 1, 3, and 7 d were administered midazolam orally at a dose of 10 mg/kg. Oral clearance of m
Publikováno v:
Biological and Pharmaceutical Bulletin. 28:1809-1812
We previously reported that a decrease in hepatic NADPH generation results in reduced hepatic first-pass clearance of propranolol in rats with bilateral ureteral ligation (BUL)-induced renal failure. The aim of the present study was to evaluate the m