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Autor:
Yuki Takada-Takatori
Publikováno v:
YAKUGAKU ZASSHI. 141:851-856
Donepezil, the most widely used drug for the treatment of Alzheimer's disease (AD), is an acetylcholinesterase (AChE) inhibitor and is thought to improve cognition by stimulating cholinergic neurotransmission. However, no correlation has yet been est
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:550-556
We previously reported a screening method for caloric restriction mimetics (CRM), a group of plant-derived compounds capable of inducing good health and longevity. In the present study, we explored the possibility of using this method to screen CRM d
Publikováno v:
YAKUGAKU ZASSHI. 141:427-431
Daptomycin (DAP) has a completely different mechanism of action compared with conventional drugs for methicillin-resistant Staphylococcus aureus (MRSA) and is widely used as the first-line drug for treatment of dermal soft tissue infection and sepsis
Autor:
Yoshihiro Natori
Publikováno v:
YAKUGAKU ZASSHI. 141:15-24
Iminosugars are one of the compounds that mimic the structure of monosaccharides. Such sugar mimics have the ability to effectively and specifically inhibit various glycosidases and glycosyltransferases. After studying iminopyranose, miglitol, which
Autor:
Masahiro Ono, Hideo Saji, Yoichi Shimizu, Hiroyuki Watanabe, Ning Ding, Takeshi Namita, Kohei Sano, Tsuyoshi Shiina
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1859-1866
Surgery remains one of the main treatments of cancer and both precise pre- and intraoperative diagnoses are crucial in order to guide the operation. We consider that using an identical probe for both pre- and intra-operative diagnoses would bridge th
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1810-1813
An elevated plasma homocysteine level is an independent risk factor for cardiovascular diseases, neurological disorders, and pregnancy complications. We recently demonstrated partial lactation failure in cystathionine γ-lyase-deficient (Cth-/-) dam
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1556-1561
Renal insufficiency secondary to contrast administration remains a prevalent and debilitating complication of angiographic procedures. Contrast-induced nephropathy (CIN) is a common clinical problem for which there is no effective medical treatment.
Autor:
Masahiro Ide, Takashi Mishima, Izumi Yoshida, Kazuhiro Fujita, Akio Watanabe, Momochika Kumagai, Yoshiki Morimoto, Keisuke Nishikawa
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:898-903
Bone loss and bone-related disease are associated with the deregulation of osteoclast function, and therefore agents that affect osteoclastogenesis have attracted attention. The purpose of the present study was to discover modified kavalactone analog
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:565-568
Bile acid sequestrants are used as medicinal drugs to treat dyslipidemia and type 2 diabetes. We found that cholestyramine, a bile acid sequestrant, increases cecal short-chain fatty acid (SCFA) production and intestinal immunoglobulin A (IgA) in C57
Autor:
Kenichi Mishima, Keiichi Irie
Publikováno v:
YAKUGAKU ZASSHI. 140:193-204
Cannabis contains over 700 known cannabinoids, terpenoids, flavonoids, and so on; however, the roles and importance of these components have yet to be fully understood. Δ9-Tetrahydrocannabinol (THC) is believed the most psychoactive component in can