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Publikováno v:
Chemical and Pharmaceutical Bulletin. 61:933-940
A series of 2-substituted phenyl derivatives of nicotinic acid 4a-l were synthesized and evaluated for their analgesic and anti-inflammatory activities. Compounds including 2-bromophenyl substituent, 4a, c, and d, proved to display distinctive analge
Autor:
Yuko Yamaguchi, Midori Wakabayashi, Toshiaki Kogure, Yoshiharu Kobayashi, Daisuke Kiyonaga, Noriko Tagawa, Masafumi Ueda, Okiko Miyata
Publikováno v:
Biological and Pharmaceutical Bulletin. 35:1275-1280
Excess glucocorticoids promote visceral obesity and insulin resistance. The main regulator of intracellular glucocorticoid levels are 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts inactive glucocorticoid into bioactive glucocor
Publikováno v:
Biological and Pharmaceutical Bulletin. 33:1977-1982
Pharmacokinetic or pharmacodynamic interactions between herbal medicines or food constituents and drugs have been studied as crucial factors determining therapeutic efficacy and outcome. Most of these interactions are attributed to inhibition or indu
Publikováno v:
Chemical and Pharmaceutical Bulletin. 55:689-728
Naturally occurring new secoiridoids published during 1994-2005 are reviewed with available physical and spectral data: mp, [alpha](D), UV, IR, (1)H- and (13)C-NMR and plant source. The works on biological and pharmacological activity of naturally oc
Autor:
Sabine Witt, Wolf-Dieter Jülich, Susanne Hessel, Elke Hammer, Timo H. J. Niedermeyer, Michael Lalk, Simone Seefeldt, Manuela Gesell, Frieder Schauer, Annett Mikolasch, Ulrike Lindequist
Publikováno v:
Chemical and Pharmaceutical Bulletin. 54:632-638
Eight novel penicillins were synthesized by heteromolecular reaction of ampicillin or amoxicillin with 2,5-dihydroxybenzoic acid derivatives using a laccase from Trametes spec. All products inhibited the growth of several gram positive bacterial stra
Publikováno v:
Biological and Pharmaceutical Bulletin. 29:1414-1417
Fossilia Mastodi OSSIS, which is a skeletal fossil of a Mastodon, an ancient mammal, has been found to have anxiolytic, sedative and anticonvulsant activities in Oriental medicine. In this study, in vivo characterization of the sedative activities of
Autor:
Shibata Mitsunobu, Eiko Matsumura, Tatsuhiko Ohe, Hiroshi Tsujibo, Yasuhiro Morita, Toshihiro Okabe, Nakao Ishida, Yoshihiko Inamori, Masaaki Sugiura, Toru Fukui
Publikováno v:
Biological and Pharmaceutical Bulletin. 27:899-902
alpha-Thujaplicin, a minor component of Aomori Hiba (Thujopsis dolabrata SIEB. et ZUCC. var. hondai MAKINO), showed rather strong antifungal activity against seven kinds of plant-pathogenic fungi, their minimum inhibitory concentrations (MICs) being
Autor:
Tsuyoshi Maekawa, Yu Momose, Masatoshi Hazama, Katsuhito Murase, Hiroyuki Tawada, Yasuo Sugiyama, Nozomu Sakai
Publikováno v:
Chemical and Pharmaceutical Bulletin. 51:565-573
A novel series of 5-(omega-aryloxyalkyl)oxazole derivatives was prepared and their effects on brain-derived neurotrophic factor (BDNF) production were evaluated in human neuroblastoma (SK-N-SH) cells. Syntheses were performed by construction of an ox
Publikováno v:
Biological & Pharmaceutical Bulletin. 26:1581-1584
The antiallergic activities of ginsenosides, which were isolated from acid-treated ginseng (Panax ginseng, Araliaceae), and their metabolites by human intestinal bacteria were measured. Ginsenoside Rh2, which is a main metabolite, had the most potent
Autor:
Ryung-Gue Kim, Kyung-Tae Lee, Young-Kwan Kim, Jongwon Choi, So-Jung Park, Hee-Juhn Park, Joohun Ha
Publikováno v:
Biological and Pharmaceutical Bulletin. 25:472-476
In the present study, effects of various hederagenin monodesmosides isolated from the stem bark of Kalopanax pictus Nakai, such as hederagenin, 5-hederin, kalopanaxsaponin A, kalopanaxsaponin 1, and sapindoside C, have been evaluated on lipopolysacch