Zobrazeno 81 - 90
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Autor:
Hisako Amino, Masafumi Ogawa, Shoji Takemura, Yoshihiko Inamori, Satomi Yamaguchi, Hiroshi Tsujibo, Mariko Tsuboi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 38:2045-2046
The diethylstilbestrol-related compounds 3,3'-dihydroxy-alpha, beta-diethyldiphenylethane (I), diethylstilbestrol (II) and hexestrol (III) showed hypotensive effects on spontaneously hypertensive rats (SHR) and antifungal activities against all Fusar
Autor:
Yumiko Asami, Kazuya Kameo, Kunio Ogawa, Kazuyuki Tomisawa, Shiuji Saito, Tohru Matsunaga, Kaoru Sota
Publikováno v:
Chemical and Pharmaceutical Bulletin. 37:1260-1267
2-Acetylthio-3-benzoylpropionic acid derivatives having two benzene rings or condensed-ring moieties were prepared, and tested for hypolipidemic activity in normal rats. Some of these compounds were active. 2-Acetylthio-3-[4-(phenylthio)benzoyl]propi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 35:4000-4015
Optically active 3-hetero analogues of isocarbacyclin (34a, 38, 39, 40 and 42) as well as ω-chain analogues have been synthesized from the bicyclic alcohol (1). Compound 34d had more potent anti-platelet aggregating activity than prostacyclin in hum
Publikováno v:
Chemical and Pharmaceutical Bulletin. 35:778-784
N- (or S-) Allyl derivatives of phenobarbital (PheB), amobarbital (AB) and thiopental (TP) were prepared, and their pharmacological activities (hypnotic activity and anticonvulsant activity against pentylenetetrazol-induced seizures) were investigate
Autor:
Kenji Yoshida, Goro Tsukamoto, Hiroshi Ohtaka, Keizo Ito, Toshiro Kanazawa, Yoshiaki Fujimoto
Publikováno v:
Chemical and Pharmaceutical Bulletin. 35:2782-2791
Analogs of 1-[ (3-alkyl-3-hydroxy-3-phenyl) propyl]-4- (2, 3, 4-trimethoxybenzyl) piperazine (1) were prepared and tested for cerebral vasodilating activity. It was found that the potency depends positively on the number of methoxyl groups on the ben
Autor:
Minoru Taguchi, Katsuo Hatayama, Morihiro Mitsukuchi, Hajime Yasui, Satoshi Abe, Shohei Higuchi, Tomoyuki Ikemoto, Kaoru Sota
Publikováno v:
Chemical and Pharmaceutical Bulletin. 37:3286-3293
A series of 21-thio derivatives of 9 alpha-fluoro-11 beta,17 alpha-dihydroxy-16 beta-methyl-1,4-pregnadiene-3, 20-dione 17-esters and related compounds were synthesized and evaluated as topical antiinflammatory agents. These compounds were prepared b
Publikováno v:
Chemical and Pharmaceutical Bulletin. 24:2739-2743
A model has been proposed to explain and determine biological response to antiarrhythmic compounds. A series of compounds was administered to mongrel dogs and tested for their ability to correct the induced arrhythmias. This drug response is shown to
Publikováno v:
Chemical and Pharmaceutical Bulletin. 34:4439-4442
Morphine congeners (5a, 5b, and 10) with pendant benzo[15-crown-5]crown ether at C-6 were synthesized. Their pharmacological properties were evaluated on 3H-naloxone binding, analgestic, and antitussive tests.
Autor:
Hitoshi Matsumoto, Hisao Kakegawa, Koichi Endo, Toshio Satoh, Itsuo Nishioka, Gen-ichiro Nonaka
Publikováno v:
Chemical and Pharmaceutical Bulletin. 33:5079-5082
The inhibitory effects of tannins on the activation of inactive hyaluronidase and on the degranulation from rat mesentery mast cells induced by compound 48/80 were investigated. Among the tested tannins, 1, 2, 3, 4, 6-penta-O-galloylglucose, 1, 2, 3,
Publikováno v:
Chemical and Pharmaceutical Bulletin. 36:2212-2219
A series of N6-alkyladenosine 3', 5'-cyclic phosphates (N6-alkyl cAMPs) (3) and N6-alkyl-8-benzylthio cAMPs (4) was synthesized from cAMP (1) and 8-benzylthio cAMP (2) by means of a one-pot reaction. This reaction proceeded by reductive alkylation in