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Publikováno v:
Biological and Pharmaceutical Bulletin. 25:137-139
The antipruritic effects of orally administered 1,4-naphthoquinone derivatives and related compounds on compound 48/80-induced scratching behavior in mice were studied. 2-Hydroxy-3-(2-hydroxyethyl)-1,4-naphthoquinone, ferulic acid, 2,2'-methylenebis(
Autor:
Atsushi Kato, Toshihiro Miura
Publikováno v:
Biological and Pharmaceutical Bulletin. 19:852-854
The hypoglycemic activity of 80% methanol extract of Polichia campestris (PM) was investigated in both normal and streptozotocin-induced diabetic mice, one of the insulin-dependent diabetic mellitus. PM (300 mg/kg) reduced the blood glucose of normal
Autor:
Akito Kawase, Tanaka Yuji, Hiroshi Shimamura, Isami Kimura, Makoto Sato, Kohji Terashima, Yasuhiro Ishizuka, Keiji Uenishi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 43:166-168
Ethyl 2-[1H-benzimidazol-2-yl)sulfinylmethyl]-4-dimethylamino-5- pyrimidinecarboxylate (2) has been synthesized and evaluated for antiulcer properties. Compound 2 is a H+/K(+)-ATPase inhibitor that affords mucosal protection against absolute ethanol-
Autor:
Keiji Uenishi, Makoto Sato, Tanaka Yuji, Isami Kimura, Yasuhiro Ishizuka, Toshiaki Kamisaki, Kohji Terashima, Teru Tanimura, Akito Kawase, Hiroshi Shimamura
Publikováno v:
Chemical and Pharmaceutical Bulletin. 43:1042-1044
With the aim of applying mast cell-stabilizing agents as antiulcer agents, N-(1H-tetrazol-5-yl)-2-anilino-5-pyrimidinecarboxamides were synthesized, and initially evaluated pharmacologically for activity in the rat passive cutaneous anaphylaxis test
Publikováno v:
Biological and Pharmaceutical Bulletin. 18:1627-1629
An acidic polysaccharide (TAP) was isolated from a hot-water extract of the fruiting bodies of Tremella aurantia. It showed remarkable hypoglycemic activity in normal mice and two diabetic mouse models, streptozotocin-induced diabetes and genetic dia
Autor:
Juichiro Shibasaki, Ryoji Konishi, Eiji Fukushima, Mitsuko Takemura, Junzo Nakamura, Hitoshi Sasaki
Publikováno v:
Journal of Pharmacobio-Dynamics. 7:804-810
The first-pass metabolism of ethenzamide (ETB), which is considered to be a prodrug of salicylamide (SAM), was studied in rats in order to compare with that of SAM. The extent of first-pass metabolism after oral ETB estimated by oral and intravenous
Publikováno v:
Chemical and Pharmaceutical Bulletin. 33:4870-4877
As a new type of norfloxacin (NFLX) prodrug, N-(5-substituted 2-oxo-1, 3-dioxol-4-yl) methyl NFLXs were designed. These N-masked NFLXs were prepared and confirmed to produce higher NFLX levels in blood than NFLX itself after oral administration to mi
Autor:
Ishikawa Katsutoshi, Reiko Tokuzen, Shoichiro Ozaki, Atsuhiko Uemura, Toshio Nagase, Yutaka Watanabe, A. Hoshi, Masaaki Iigo, Hiroyuki Furukawa, Haruki Mori, Tomio Ogasawara, Tomonori Hoshiko
Publikováno v:
Chemical and Pharmaceutical Bulletin. 34:150-157
With the aim of diminishing the toxicity of 5-fluorouracil (1) and obtaining biologically active derivatives of 1 suitable for oral administration, α-alkoxyalkyl groups were introduced at the 1-, 3-and 1, 3-positions of 1. Alkoxyalkylation can be ef