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Publikováno v:
Chemical and Pharmaceutical Bulletin. 61:933-940
A series of 2-substituted phenyl derivatives of nicotinic acid 4a-l were synthesized and evaluated for their analgesic and anti-inflammatory activities. Compounds including 2-bromophenyl substituent, 4a, c, and d, proved to display distinctive analge
Publikováno v:
Chemical and Pharmaceutical Bulletin. 55:689-728
Naturally occurring new secoiridoids published during 1994-2005 are reviewed with available physical and spectral data: mp, [alpha](D), UV, IR, (1)H- and (13)C-NMR and plant source. The works on biological and pharmacological activity of naturally oc
Autor:
Sabine Witt, Wolf-Dieter Jülich, Susanne Hessel, Elke Hammer, Timo H. J. Niedermeyer, Michael Lalk, Simone Seefeldt, Manuela Gesell, Frieder Schauer, Annett Mikolasch, Ulrike Lindequist
Publikováno v:
Chemical and Pharmaceutical Bulletin. 54:632-638
Eight novel penicillins were synthesized by heteromolecular reaction of ampicillin or amoxicillin with 2,5-dihydroxybenzoic acid derivatives using a laccase from Trametes spec. All products inhibited the growth of several gram positive bacterial stra
Publikováno v:
Biological and Pharmaceutical Bulletin. 29:1414-1417
Fossilia Mastodi OSSIS, which is a skeletal fossil of a Mastodon, an ancient mammal, has been found to have anxiolytic, sedative and anticonvulsant activities in Oriental medicine. In this study, in vivo characterization of the sedative activities of
Publikováno v:
Biological & Pharmaceutical Bulletin. 25:1608-1613
The aims of this study were to examine the enhancing effects of aloe-emodin anthrone (AEA) on the colonic membrane permeability of water-soluble and poorly permeable compounds and to clarify the mechanism of the permeation-enhancing activity of AEA.
Publikováno v:
Biological and Pharmaceutical Bulletin. 22:816-821
To overcome the side effects of steroids, novel steroid-17-yl methyl glycolates with succinyl group at C-20, derived from prednisolone and dexamethasone were prepared based on a concept of the antedrug. Their topical anti-inflammatory activity and sy
Publikováno v:
Chemical and Pharmaceutical Bulletin. 54:836-838
The photochemistry of anti-inflammatory drug desonide (De, 1) was studied in aerobic as well as in anaerobic condition with different irradiation wavelengths (254, 310 nm) in acetonitrile and 2-propanol. All photoproducts obtained were isolated and c
Publikováno v:
Biological and Pharmaceutical Bulletin. 17:784-788
Fucoidan, a sulfated poly (L-fucopyranose), is an effective anticoagulant in vitro and in vivo. In the present study, an aminated derivative of fucoidan was prepared and examined for its fibrinolytic and anticoagulant activities. The aminated derivat
Autor:
Tetsuyuki Ikeda, Hideki Miyataka, Hitoshi Matsumoto, Hiroki Ueda, Hisao Kakegawa, Toshio Satoh
Publikováno v:
Chemical and Pharmaceutical Bulletin. 41:1387-1390
A novel series of 4-guanidinomethylbenzoic acid (GMBA) arylamides was synthesized. Several showed more potent inhibitory effects on stress-induced gastric lesion in rats than cetraxate. We selected 4-guanidinomethylbenzoic acid (2'-ethoxycarbonyl)phe
Publikováno v:
Chemical and Pharmaceutical Bulletin. 49:111-113
Methyl (2), ethyl (3), propyl (4), butyl (5), allyl (6), benzyl (7), o-, m-, p-xylyl (8-10), and alpha-phenylethyl (11) derivatives of arabinofuranosyluracil (1) were synthesized and their pharmacological effects in mice were examined by using hypnot