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Autor:
Kimie Nakagawa
Publikováno v:
YAKUGAKU ZASSHI. 141:669-674
Vitamin K is a fat-soluble vitamin that plays an important role in blood coagulation and bone formation. Vitamin K has homologues due to differences in the side chain structure, phylloquinone (abbreviated as vitamin K1, PK) having a phytyl side chain
Autor:
Seiichiro Himeno, Hitomi Fujishiro
Publikováno v:
YAKUGAKU ZASSHI. 141:695-703
Cellular transport systems for both essential and toxic trace elements remain elusive. In our studies on the transport systems for cadmium (Cd), we found that the cellular uptake of Cd is mediated by the transporter for manganese (Mn). We identified
Autor:
Yoshihiro Natori
Publikováno v:
YAKUGAKU ZASSHI. 141:15-24
Iminosugars are one of the compounds that mimic the structure of monosaccharides. Such sugar mimics have the ability to effectively and specifically inhibit various glycosidases and glycosyltransferases. After studying iminopyranose, miglitol, which
Autor:
Ryosuke Mitsuhashi, Kentaro Kogure, Dai Majima, Kazuaki Kajimoto, Tatsuya Fukuta, Misaki Yamasaki
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:46-50
Obesity is a pathological state related to various lifestyle-related diseases, such as diabetes and dyslipidemia, that may be prevented through the development of anti-obesity treatments. Lipid accumulation in cells could be affected by vitamin E est
Autor:
Hironori Kanda, Yoshito Kumagai
Publikováno v:
YAKUGAKU ZASSHI. 140:1119-1128
Humans are exposed to various xenobiotic electrophiles on a daily basis. Electrophiles form covalent adducts with nucleophilic residues of proteins. Redox signaling, which consists of effector molecules (e.g., kinases and transcription factors) and r
Publikováno v:
Chemical and Pharmaceutical Bulletin. 68:201-211
Auristatins are important payloads used in antibody drug conjugates (ADCs), and the most well-known compound family member, monomethyl auristatin (MMAE), is used in two Food and Drug Administration (FDA)-approved ADCs, Adcetris® and Polivy®. Multip
Autor:
Guangpu Liu, Juan Yang, Haifang Hao, Yang Jiao, Yongqiang Lin, Yanli Dou, Cheng-Shi Jiang, Ping Chang
Publikováno v:
Chemical and Pharmaceutical Bulletin. 68:161-166
Discovery of novel multifunctional inhibitors targeting acetylcholinesterase (AChE) has becoming a hot spot in anti-Alzheimer's disease (AD) drug development. In the present study, four potent small molecule inhibitors (A01, A02, A03 and A04) of AChE
Autor:
Lakki Pramod Kumar Reddy, Saravanan Manigandan, Musa Al Murad, Shivam H Karadkar, Johnsamuel Godwin Christopher, Rajendran Harishkumar, Chinnadurai Immanuel Selvaraj, Saravanan Sibi Karthik
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:1969-1976
In recent years, numerous research outcomes were established on various naturally occurring compounds that have been shown to have beneficial antioxidant and other biological activities. Antioxidant defence mechanism plays a vital role in combating v
Publikováno v:
Chemical and Pharmaceutical Bulletin. 67:1201-1207
Oleanolic acid (OA) was discovered as a mild influenza hemagglutinin (HA) inhibitor in our earlier studies. In the present work, 20 compounds were prepared by structural modifications of OA, and their antiviral activities against influenza A/WSN/33 (
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:1199-1206
Metalloporphyrin derivatives have been investigated for their therapeutic potential for oxidative stress-related diseases because of their scavenging of reactive oxygen species (ROS). Here, we describe the synthesis, physicochemical properties, and R