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Autor:
Shizuo Narimatsu, Tetsuo Satoh, Yoshihiko Funae, Hiroyuki Hichiya, Takashi Isobe, Sumio Shinoda, Shigeo Yamamoto, Nobumitsu Hanioka, Shigeru Yamano
Publikováno v:
Biological and Pharmaceutical Bulletin. 28:634-640
Inhibitory effects of desipramine (DMI) on rat and human CYP2D enzymes were studied using bufuralol (BF) 1''-hydroxylation as an index. Inhibition was examined under the following two conditions: 1) DMI was co-incubated with BF and NADPH in the react
Autor:
Ikuo Yamamoto, Shinsuke Higuchi, Takashi Kageyama, Kazuhito Watanabe, Tamihide Matsunaga, Shigeru Ohmori
Publikováno v:
Biological and Pharmaceutical Bulletin. 28:646-651
The NADH-dependent activity by hepatic microsomes of Japanese monkeys for 7-oxo-Delta(8)-tetrahydrocannabinol (7-oxo-Delta(8)-THC) formation from 7beta-hydroxy-Delta(8)-THC exhibited about 70% of the NADPH-dependent activity (100%) at the substrate c
Publikováno v:
Biological and Pharmaceutical Bulletin. 26:216-219
Propofol (2,6-diisopropylphenol), widely used an intravenous anesthetic, is rapidly metabolized to its glucuronide in the in vivo studies. Kinetic parameters for the glucuronidation of propofol and its analogs, such as 2,5-diisopropylphenol, 2-tert-b
Autor:
Aki Tsuyuki, Kayoko Suzuki, Masamichi Fukuoka, Reiko Matsushita, Kumiko Ohta, Chizuru Yamamoto, Yoshiaki Matsumoto, Makiko Shimizu
Publikováno v:
Biological and Pharmaceutical Bulletin. 26:675-682
This study was conducted to explore the mechanism of the pharmacokinetic interaction between aspirin (ASP) and indomethacin (IND) using rat erythrocytes (RBCs) and hepatocytes. ASP was hydrolyzed to salicylic acid (SA) in both the RBCs and hepatocyte
Publikováno v:
Biological and Pharmaceutical Bulletin. 25:397-400
It was demonstrated that trans-stilbene was metabolically activated to the estrogenic compound by rat liver microsomes (Sugihara et al., Toxicol. Appl. Pharmacol., 167, 46-54 (2000)). In this study, determination of the isoforms of cytochrome P450 in
Publikováno v:
Biological and Pharmaceutical Bulletin. 24:1263-1266
In vitro studies were conducted to identify human drug-metabolizing enzymes involved in the metabolism of SNI-2011 ((+/-)-cis-2-methylspiro [1,3-oxathiolane-5,3'-quinuclidine] monohydrochloride hemihydrate, cevimeline hydrochloride hydrate). When 14C
Autor:
Tadanori Sasaki, Takashi Tobe, Yasuna Kobayashi, Toshinori Yamamoto, Naomi Ohshiro, Shogo Tokuyama, Takemi Yoshida
Publikováno v:
Biological and Pharmaceutical Bulletin. 24:505-509
The effect of 4-(4-chlorobenzyl)pyridine (4-CBP) on rat hepatic microsomal cytochrome P450 (P450) and its molecular species (CYP2B1, 2E1, 3A2, 2C11, and 2C12), and on drug-metabolizing enzyme activities were examined in vivo and in vitro. Treatment o
Publikováno v:
Biological and Pharmaceutical Bulletin. 21:421-425
By determining the formation amount of isonicotinic acid (INA) from isonicotinic acid hydrazide (isoniazid : INH) in isolated rat hepatocytes, we were able to identify the involvement of the oxidative cleavage of the acid hydrazide. INA formation fro
Publikováno v:
Biological and Pharmaceutical Bulletin. 20:315-321
The effect of gemfibrozil, and analogue of clofibric acid, on the centrifugal behavior of peroxisomes and activity of peroxisomal enzymes involved in lipid metabolism was studied. Rats were fed chow containing 0.2% gemfibrozil for 2 weeks. Nycodenz g
Autor:
Satomi Takai, Tadashi Sugiyama, Libiao Luan, Kazuyuki Hirano, Yoshiko Usami, Tetsuo Adachi, Yoshihiro Katagiri
Publikováno v:
Biological and Pharmaceutical Bulletin. 20:71-75
Two carboxylesterases with pI 6.0 and 6.2 derived from rat liver microsomes were purified. The two isozymes were remarkably different in substrate specificity, but they had equal enzymatic activity for alpha-naphthyl acetate and were inhibited equall