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Autor:
Yan Chen, Yan Zhou, Bingxue Sun, Yanan Sun, Mengshu Wang, Shubo Liu, Yong Zhang, Wei Kong, Feng Li
Publikováno v:
Biological & Pharmaceutical Bulletin. 39:42-48
The purpose of this study was to investigate the gastrointestinal stability of exenatide to determine the key factor(s) contributing to peptide degradation during the oral delivery process. The effects of pH and various digestive enzymes on the degra
Publikováno v:
Biological and Pharmaceutical Bulletin. 32:640-645
The structural similarity between papaverine and berberine, a known inhibitor of human protein tyrosine phosphatase 1B (h-PTP 1B), prompted us to investigate the potential of papaverine as h-PTP 1B inhibitor. The investigation included simulated dock
Autor:
Hitoshi Nakayama
Publikováno v:
YAKUGAKU ZASSHI. 128:1631-1643
Introduction to bioorganic chemistry by Prof. Kanaoka at the entrance of my research works affects greatly throughout the life afterward. Chemical modification studies of enzyme proteins taught me quality of chemical reactions. For example, triethylo
Autor:
Satoshi Endo, Kengo Matsumoto, Shuhei Ishikura, Ossama El-Kabbani, Toshiyuki Matsunaga, Kazuo Tajima, Akira Hara
Publikováno v:
Biological and Pharmaceutical Bulletin. 29:539-542
AKR1C20, a member of the aldo-keto reductase (AKR) superfamily, found by mouse genomic analysis, exhibits the highest sequence identity (89%) with mouse liver 17beta-hydroxysteroid dehydrogenase (HSD) type 5, but its function remains unknown. In this
Autor:
Shizuo Narimatsu, Tetsuo Satoh, Yoshihiko Funae, Hiroyuki Hichiya, Takashi Isobe, Sumio Shinoda, Shigeo Yamamoto, Nobumitsu Hanioka, Shigeru Yamano
Publikováno v:
Biological and Pharmaceutical Bulletin. 28:634-640
Inhibitory effects of desipramine (DMI) on rat and human CYP2D enzymes were studied using bufuralol (BF) 1''-hydroxylation as an index. Inhibition was examined under the following two conditions: 1) DMI was co-incubated with BF and NADPH in the react
Autor:
Ikuo Yamamoto, Shinsuke Higuchi, Takashi Kageyama, Kazuhito Watanabe, Tamihide Matsunaga, Shigeru Ohmori
Publikováno v:
Biological and Pharmaceutical Bulletin. 28:646-651
The NADH-dependent activity by hepatic microsomes of Japanese monkeys for 7-oxo-Delta(8)-tetrahydrocannabinol (7-oxo-Delta(8)-THC) formation from 7beta-hydroxy-Delta(8)-THC exhibited about 70% of the NADPH-dependent activity (100%) at the substrate c
Autor:
Eun-Kyung Park, Hyung-Sup Bae, Young-Suk Kim, Sang-Kwan Moon, Ki-Ho Cho, Woo Sang Jung, Dong-Hyun Kim
Publikováno v:
Biological and Pharmaceutical Bulletin. 27:1810-1813
Chunghyuldan (Daio-Orengedokuto in Japanese) (CHD) has been used as an antihyperlipidemic and antiischemic agent in Korea. To evaluate in vitro the efficacy of Chunghyuldans (CHDs) metabolized with and without human intestinal microflora against brai
Publikováno v:
Biological and Pharmaceutical Bulletin. 26:295-298
An acid sialidase partially purified from porcine liver was activated by incubation at 37 degrees C under acidic pH. This activation was dependent on pH, time and temperature, but not inhibited by amastatin, an inhibitor of aminopeptidase A, in contr
Autor:
Eugene Bratoeff, Elena Ramírez, Eugenio Flores, Ivonne Heuze, Norma Valencia, Mauricio Sánchez, Marisa Cabeza
Publikováno v:
Chemical and Pharmaceutical Bulletin. 51:1132-1136
The in vitro inhibitory activity of five new progesterone derivatives: 17alpha-hydroxy-16beta-methylpregna-1,4,6-triene-3,20-dione 1; 16beta-methyl-17alpha-toluoyloxypregna-1,4,6-triene-3,20-dione 2; 17alpha-hydroxy-6-methylenepregn-4-ene-3,20-dione
Publikováno v:
Biological and Pharmaceutical Bulletin. 25:397-400
It was demonstrated that trans-stilbene was metabolically activated to the estrogenic compound by rat liver microsomes (Sugihara et al., Toxicol. Appl. Pharmacol., 167, 46-54 (2000)). In this study, determination of the isoforms of cytochrome P450 in