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Autor:
Yoshihiro Natori
Publikováno v:
YAKUGAKU ZASSHI. 141:15-24
Iminosugars are one of the compounds that mimic the structure of monosaccharides. Such sugar mimics have the ability to effectively and specifically inhibit various glycosidases and glycosyltransferases. After studying iminopyranose, miglitol, which
Autor:
Yan Chen, Yan Zhou, Bingxue Sun, Yanan Sun, Mengshu Wang, Shubo Liu, Yong Zhang, Wei Kong, Feng Li
Publikováno v:
Biological & Pharmaceutical Bulletin. 39:42-48
The purpose of this study was to investigate the gastrointestinal stability of exenatide to determine the key factor(s) contributing to peptide degradation during the oral delivery process. The effects of pH and various digestive enzymes on the degra
Autor:
Ji-min Park, Hae-Jun Lee, Dae-Sik Jang, Kyung-Tae Lee, Woo-Seok Lee, Heon-Yong Shim, Ji-Sun Shin
Publikováno v:
Biological & Pharmaceutical Bulletin. 39:657-664
We investigated the effect of chikusetsusaponin IVa (CS) and chikusetsusaponin IVa methyl ester (CS-ME) from the roots of Achyranthes japonica NAKAI on lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW26
Autor:
Noritaka Nakamichi, Takuya Shimizu, Yusuke Masuo, Ai Kijima, Saki Takahashi, Tomoko Sugiura, Takahiro Ishimoto, Yukio Kato
Publikováno v:
Biological & Pharmaceutical Bulletin. 38:774-780
5-Aminosalicylic acid (5-ASA) is an orally administered therapeutic agent for inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease. We hypothesized that the absorption of 5-ASA is mediated by the polyspecific carnitine/organic
Autor:
Kyung-Tae Lee, Byeol Ryu, Ji-Sun Shin, Hwi-Ho Lee, Young-Wuk Cho, Nam-Jung Kim, Yujin Hong, Dae Sik Jang
Publikováno v:
Biological & Pharmaceutical Bulletin. 38:1081-1086
To identify bioactive natural products possessing anti-inflammatory activity, the potential of fulgidic acid from the rhizomes of Cyperus rotundus and the underlying mechanisms involved in its anti-inflammatory activity were evaluated in this study.
Publikováno v:
Biological and Pharmaceutical Bulletin. 37:618-624
Uridine 5'-diphosphate (UDP)-glucuronosyltransferase 1A (UGT1A), which catalyzes major phase II reactions, is regulated by endogenous and exogenous factors via nuclear receptors such as the aryl hydrocarbon receptor (AhR). Glucocorticoid, one of the
Publikováno v:
Biological and Pharmaceutical Bulletin. 35:2192-2197
Grape seed proanthocyanidin extracts (GSPE) belonging to polyphenols, possess various biological effects including anti-inflammation, anti-oxidant, anti-aging, anti-atherosclerosis, etc. GSPE is potential in regulating endothelial function. However,
Autor:
Izuru Kakuta, Kiyomi Takase
Publikováno v:
YAKUGAKU ZASSHI. 131:1473-1481
The present study was carried out to examine the chemopreventive effects of 5-fluorouracil (5-FU) and lactoferrin (LF) on goldfish intestinal carcinogenesis induced by 1,2-dimethylhydrazine (DMH). DMH was given to fish by intraperitoneal injection in
Autor:
Shi-Yong Ryu, Y. J. Kim, Gil-Tae Gang, Jung-Ran Noh, Keum-Jin Yang, Chul-Ho Lee, Sang Kyum Kim, Hyun-Sun Lee, Yong-Hoon Kim
Publikováno v:
Biological and Pharmaceutical Bulletin. 33:450-454
Platycodon grandiflorum (PG) (Korean name, Doraji; Chinese name, Jiegeng; and Japanese name, Kikyo) is a perennial plant in the Campanulaceae family that contains triterpenoid saponins, carbohydrates, and fibers. This study was carried out to investi
Publikováno v:
Biological and Pharmaceutical Bulletin. 33:128-132
Coffee is a popular beverage worldwide with various nutritional benefits. Diterpene cafestol, one of the major components of coffee, contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic,