Zobrazeno 1 - 10
of 119
pro vyhledávání: ''
Publikováno v:
Biological and Pharmaceutical Bulletin. 41:690-696
The purpose of this study was to determine the effects of different concentrations of ligustrazine, an extract from Chinese herb, on ketamine requirement for hypnosis and analgesia in mice. In the hypnotic response study, mice were randomly allocated
Autor:
Jiaping Guo, Changchun Kuang, Shi Zhen, Dezong Li, Xudong Fu, Huilin Zeng, Huhai Chen, Xiangyang Xie, Hong Liu
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 65:229-235
Postoperative pain is a complex physiological response to disease and tissue injury. Moderate-to-severe pain typically occurs within 48 h after surgery. Amino amide local anesthetics are widely applied to manage postoperative pain, and they have high
Publikováno v:
Biological & Pharmaceutical Bulletin. 40:1432-1438
Diabetic neuropathy pain (DNP) is a common chronic complication of diabetes characterized by spontaneous pain, hyperalgesia and allodynia. Dexmedetomidine is a selective α2 adrenergic agonist that relieves sympathetic nervous tension and reduces the
Autor:
Isamu Murata, Ikuo Kanamoto, Masayuki Kimura, Yutaka Inoue, Narutoshi Arai, Aishi Fukushima, Astuko Saito
Publikováno v:
YAKUGAKU ZASSHI. 135:1049-1055
Cancer patients often report a decreased quality of life due to cancer-related pain, especially neuropathic pain, which is difficult to manage and often develops resistance to morphine. Thus a supplementary analgesic can play an important role in the
Autor:
Yasushi Kuraishi
Publikováno v:
YAKUGAKU ZASSHI. 134:1125-1142
This review describes my research for the past 39 years regarding the pharmacology of pain and analgesia. We have demonstrated that the descending noradrenergic system is involved in the analgesic effect of morphine injected into the nucleus reticula
Autor:
Yukio Takano
Publikováno v:
YAKUGAKU ZASSHI. 134:997-1005
Pain control is very important since, even today, 20 million people suffer from neuropathic pain. Although many basic science and clinical researchers have made efforts to control pain, the mechanism of neuropathic pain is unfortunately still not ful
Autor:
Minako Matsumoto, Tadashi Mikami, Tatsuya Ohtsubo, Kana Komesu, Takumi Tsuji, Rie Banno, Yuya Yoshida, Miho Sudou, Takayo Umeyama, Takeyuki Kohno
Publikováno v:
YAKUGAKU ZASSHI. 134:981-986
The anticancer drug dacarbazine (DTIC) is photosensitive, and the photodegradation product 5-diazoimidazole-4-carboxamide (diazo-IC) induces adverse reactions including local venous pain during intravenous injection. In this study we evaluated the ef
Autor:
Akinori Akaike, Yoshinori Kobayashi, Tatsuo Fukuda, Yuka Omameuda, Michiho Ito, Shuji Kaneko, Hiroaki Takemoto
Publikováno v:
Biological and Pharmaceutical Bulletin. 37(6):1050-1055
Dried Nardostachys chinensis roots contain sesquiterpenoids that are widely used as herbal tranquilizers. We previously identified the highly sedative sesquiterpenoid valerena-4, 7(11)-diene (VLD) from this plant. In the present study, we investigate
Publikováno v:
Biological and Pharmaceutical Bulletin. 37:858-864
Diabetic neuropathy is characterized by progressive degeneration of nerve fibers associated with diabetes mellitus. Antidepressants and anticonvulsants are the mainstay of pharmacological treatment, but are often limited in effectiveness against the
Publikováno v:
Biological and Pharmaceutical Bulletin. 37:1816-1819
Pregabalin, (S)-3-isobutyl-γ-aminobutyric acid (GABA), is a widely used adjuvant therapy for patients with neuropathic pain, which is defined as chronic pain caused by lesions or diseases of the somatosensory nervous system. However, dizziness and s