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Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 64:1607-1615
The primary objective of the present study was to develop extended-release matrix formulations of apremilast for the oral delivery and to study their in vitro and in vivo correlation. Five extended-release formulations containing hydroxypropylmethylc
Publikováno v:
YAKUGAKU ZASSHI. 128:1341-1345
In this study, as an approach to possible pharmacokinetic interactions between antidiabetic agents and health foods, we investigated the binding of metformin and glibenclamide to aojiru, kurosu, and blueberry extract using a dialysis method. The perm
Publikováno v:
Biological and Pharmaceutical Bulletin. 25:779-782
The objective of this study was to construct a modified equation for the delivery of a drug by iontophoresis. Indomethacin was selected as a model since it has been widely used as a non-steroidal anti-inflammatory drug (NSAID) for external pharmaceut
Publikováno v:
Biological and Pharmaceutical Bulletin. 24:278-283
The effect of drug lipophilicity on in vivo iontophoretic transdermal absorption was evaluated. Non-steroidal anti-inflammatory drugs (NSAIDs) were selected as model drugs with a wide range of lipophilicity: salicylic acid (SA), ketoprofen (KP), napr
Autor:
Hitoshi Sasaki, Masataka Ichikawa, Junzo Nakamura, Takahiro Mukai, Mikiro Nakashima, Koyo Nishida, Kenzo Yamamura
Publikováno v:
Biological and Pharmaceutical Bulletin. 23:1352-1356
We previously developed an in vivo pharmacokinetic model that accounts for the corneal diffusion in albino rabbits and predicts the concentration of beta-blockers in the anterior segments. The purpose of this study is to pharmacokinetically predict t
Publikováno v:
Biological and Pharmaceutical Bulletin. 23:632-636
The objective of our study is to establish a novel method for the in vivo evaluation of transdermal delivery. In this study, cathodal iontophoresis of ketoprofen, a nonsteroidal anti-inflammatory drug, was performed in the thoracic area of rats at a
Publikováno v:
Journal of Pharmacobio-Dynamics. 9:787-792
The pharmacokinetics of sulfaguanidine in rats was studied after its intravenous or oral administration. In adult rats, its elimination from plasma, after intravenous administration of 2.5 or 25 mg/kg doses, could be described by a two-compartment op