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Publikováno v:
Biological and Pharmaceutical Bulletin. 37:1661-1667
A transdermal oil-in-water type emulsified formulation containing propiverine hydrochloride, used for treatment of an overactive bladder (OAB), was evaluated for in vitro skin permeation under finite conditions and in vivo transdermal absorption. Pro
Autor:
Kimio Tatsuishi, Tsuneji Nagai, Masanori Kayano, Yuki Tsushima, Yoshiharu Machida, Tadakazu Tokumura
Publikováno v:
Chemical and Pharmaceutical Bulletin. 34:1275-1279
This investigation was aimed at the improvement of the bioavailability of cinnarizine (CN) by administering its β-cyclodextrin (β-CD) complex together with a competing agent. The ability of L-leucine (L-Leu) and L-isoleucine (L-Ileu) to act as comp
Autor:
Tadakazu Tokumura, Kimio Tatsuishi, Masanori Kayano, Yoshiharu Machida, Yuki Tsushima, Tsuneji Nagai
Publikováno v:
Chemical and Pharmaceutical Bulletin. 33:2962-2967
The bioavailability of cinnarizine (CN) upon oral administration of its β-cyclodextrin complex to beagle dogs was investigated in comparison with that of CN alone. The dissolution rate at pH 3.0-6.8 was increased significantly by inclusion complexat
Publikováno v:
Journal of Pharmacobio-Dynamics. 9:787-792
The pharmacokinetics of sulfaguanidine in rats was studied after its intravenous or oral administration. In adult rats, its elimination from plasma, after intravenous administration of 2.5 or 25 mg/kg doses, could be described by a two-compartment op