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Autor:
Tsumugi Eifuku, Noriaki Nagai, Tomonori Hayashi, Hinako Kawaguchi, Atsufumi Kawabata, Hiroshi Matsuoka
Publikováno v:
Chemical and Pharmaceutical Bulletin. 68:879-884
The percutaneous absorption of a fentanyl (FEN)-patch is affected by various external factors including the volume of sebum secretion, which causes changes in the skin surface environment. In this study, we prepared a lard-based sebum-like secretion
Autor:
Valeria Pereira de Sousa, Lucio Mendes Cabral, Eduardo Costa Pinto, Kerolayne de Castro Bezerra
Publikováno v:
Chemical and Pharmaceutical Bulletin. 66:701-707
Gliclazide (GLZ) is a second generation hypoglycemic drug used for the treatment of Type 2 diabetes mellitus. The low solubility of GLZ has been described as the rate limiting step for drug dissolution and absorption, thus a prediction of its in vivo
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 64:1607-1615
The primary objective of the present study was to develop extended-release matrix formulations of apremilast for the oral delivery and to study their in vitro and in vivo correlation. Five extended-release formulations containing hydroxypropylmethylc
Publikováno v:
Biological and Pharmaceutical Bulletin. 37:1661-1667
A transdermal oil-in-water type emulsified formulation containing propiverine hydrochloride, used for treatment of an overactive bladder (OAB), was evaluated for in vitro skin permeation under finite conditions and in vivo transdermal absorption. Pro
Publikováno v:
Chemical and Pharmaceutical Bulletin. 62:1000-1008
In this study a brinzolamide drug-resin ophthalmic thermosensitive in situ gelling system was developed and evaluated. Brinzolamide was combined with ion exchange resins to prolong the retention time of drugs in the eye and to reduce ocular and syste
Autor:
Osamu Hosoya, Yuya Egawa, Rina Yajima, Kazuhiko Juni, Chihiro Suzuki, Toshinobu Seki, Shinji Oshima
Publikováno v:
Biological and Pharmaceutical Bulletin. 35:203-209
Studies on drug disposition in inflamed skin are important for safe and effective application of topical drugs. Here, the absorption of flurbiprofen (FP) through inflamed skin was examined in vivo and in a skin-mimicking artificial model system. The
Publikováno v:
Biological and Pharmaceutical Bulletin. 25:779-782
The objective of this study was to construct a modified equation for the delivery of a drug by iontophoresis. Indomethacin was selected as a model since it has been widely used as a non-steroidal anti-inflammatory drug (NSAID) for external pharmaceut
Publikováno v:
Biological and Pharmaceutical Bulletin. 24:278-283
The effect of drug lipophilicity on in vivo iontophoretic transdermal absorption was evaluated. Non-steroidal anti-inflammatory drugs (NSAIDs) were selected as model drugs with a wide range of lipophilicity: salicylic acid (SA), ketoprofen (KP), napr
Autor:
Hitoshi Sasaki, Masataka Ichikawa, Junzo Nakamura, Takahiro Mukai, Mikiro Nakashima, Koyo Nishida, Kenzo Yamamura
Publikováno v:
Biological and Pharmaceutical Bulletin. 23:1352-1356
We previously developed an in vivo pharmacokinetic model that accounts for the corneal diffusion in albino rabbits and predicts the concentration of beta-blockers in the anterior segments. The purpose of this study is to pharmacokinetically predict t
Publikováno v:
Biological and Pharmaceutical Bulletin. 23:632-636
The objective of our study is to establish a novel method for the in vivo evaluation of transdermal delivery. In this study, cathodal iontophoresis of ketoprofen, a nonsteroidal anti-inflammatory drug, was performed in the thoracic area of rats at a