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Autor:
Tsumugi Eifuku, Noriaki Nagai, Tomonori Hayashi, Hinako Kawaguchi, Atsufumi Kawabata, Hiroshi Matsuoka
Publikováno v:
Chemical and Pharmaceutical Bulletin. 68:879-884
The percutaneous absorption of a fentanyl (FEN)-patch is affected by various external factors including the volume of sebum secretion, which causes changes in the skin surface environment. In this study, we prepared a lard-based sebum-like secretion
Autor:
Valeria Pereira de Sousa, Lucio Mendes Cabral, Eduardo Costa Pinto, Kerolayne de Castro Bezerra
Publikováno v:
Chemical and Pharmaceutical Bulletin. 66:701-707
Gliclazide (GLZ) is a second generation hypoglycemic drug used for the treatment of Type 2 diabetes mellitus. The low solubility of GLZ has been described as the rate limiting step for drug dissolution and absorption, thus a prediction of its in vivo
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 64:1607-1615
The primary objective of the present study was to develop extended-release matrix formulations of apremilast for the oral delivery and to study their in vitro and in vivo correlation. Five extended-release formulations containing hydroxypropylmethylc
Publikováno v:
Chemical and Pharmaceutical Bulletin. 62:1000-1008
In this study a brinzolamide drug-resin ophthalmic thermosensitive in situ gelling system was developed and evaluated. Brinzolamide was combined with ion exchange resins to prolong the retention time of drugs in the eye and to reduce ocular and syste
Autor:
Kimio Tatsuishi, Tsuneji Nagai, Masanori Kayano, Yuki Tsushima, Yoshiharu Machida, Tadakazu Tokumura
Publikováno v:
Chemical and Pharmaceutical Bulletin. 34:1275-1279
This investigation was aimed at the improvement of the bioavailability of cinnarizine (CN) by administering its β-cyclodextrin (β-CD) complex together with a competing agent. The ability of L-leucine (L-Leu) and L-isoleucine (L-Ileu) to act as comp
Publikováno v:
Chemical and Pharmaceutical Bulletin. 32:1967-1972
The effect of chloral hydrate (CH) on the in vivo and in vitro binding of sulfamethoxazole (SMX) to plasma proteins was investigated in rabbits. CH clearly reduced the in vivo binding of SMX to plasma proteins. On the other hand, CH had no effect on
Autor:
Tadakazu Tokumura, Kimio Tatsuishi, Masanori Kayano, Yoshiharu Machida, Yuki Tsushima, Tsuneji Nagai
Publikováno v:
Chemical and Pharmaceutical Bulletin. 33:2962-2967
The bioavailability of cinnarizine (CN) upon oral administration of its β-cyclodextrin complex to beagle dogs was investigated in comparison with that of CN alone. The dissolution rate at pH 3.0-6.8 was increased significantly by inclusion complexat
Publikováno v:
Chemical and Pharmaceutical Bulletin. 33:5113-5118
Percutaneous absorption and skin metabolism of 3H-hydrocortisone butyrate propionate, as a diester derivative of hydrocortisone, were studied in vivo. The agent was dissolved in saline and applied to the shaved abdominal skin of dogs. Most of the abs