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Autor:
Hitoshi Sasaki, Masataka Ichikawa, Junzo Nakamura, Takahiro Mukai, Mikiro Nakashima, Koyo Nishida, Kenzo Yamamura
Publikováno v:
Biological and Pharmaceutical Bulletin. 23:1352-1356
We previously developed an in vivo pharmacokinetic model that accounts for the corneal diffusion in albino rabbits and predicts the concentration of beta-blockers in the anterior segments. The purpose of this study is to pharmacokinetically predict t
Publikováno v:
Journal of Pharmacobio-Dynamics. 14:567-575
Four commercial controlled-release tablets of d-chlorpheniramine maleate, which showed various drug release properties, were administered to beagle dogs, and the correlation between in vitro drug release and in vivo absorption was studied. The mean i